J. W. Schoggins

This paper develops a mutant ACE2 that neutralizes SARS-CoV-2 in vivo through aerosolized delivery, demonstrating its protective effect in a mouse model.

This study identifies a limited set of interferon-stimulated genes that mediate antiviral effects against Venezuelan equine encephalitis virus.

This study shows LY6E protects mice from murine coronavirus and SARS-CoV-2 by acting in specific immune cells and reducing secretory cell-associated gene expression.

The paper identifies host factors required for ribosome formation and viral replication using CRISPR screening, showing that SPATA5 and SBDS are broadly needed for multiple virus types.

This paper identifies a mechanism by which oxysterols like 25HC deplete accessible cholesterol from plasma membranes via ACAT activation and SREBP suppression to restrict microbial infection.

The paper screens interferon-stimulated genes to identify RARRES3 as a factor restricting Toxoplasma gondii infection by inducing premature parasite egress.

This study identifies LY6E as an interferon-induced gene that restricts coronavirus entry and pathogenesis by inhibiting spike protein-mediated fusion and protecting immune cells.