Author

K. Aoshima

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 4 Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Kobayashi· 3 shared T. Kimura· 3 shared K. C. M. Gulay· 2 shared Q. Yan· 2 shared A. Aoshima· 1 shared C. J. Booth· 1 shared D. E. Siekhaus· 1 shared D. Rimm· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersCancer Biology

A. Kobayashi

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Distinct role of TGN-resident clathrin adaptors for Rab5 activation in the TGN-endosome trafficking pathway

M. Nagano, K. Aoshima, H. Shimamura, D. E. Siekhaus, J. Y. Toshima, J. Toshima

The paper investigates the role of clathrin adaptors in Rab5 activation during TGN-endosome trafficking, showing AP-1 and GGAs have distinct functions in this process.

bioRxiv · Mar 27, 2023 · PreprintCell Biology

Manipulating Histone Acetylation Leads to Adverse Effects in Hemangiosarcoma Cells

T. Suzuki, K. Aoshima, J. Yamazaki, A. Kobayashi, T. Kimura

This study investigates the effects of histone acetylation manipulation using HDACi and BETi on canine hemangiosarcoma cells, finding that SAHA and JQ1 induce apoptosis and anti-tumour immunity, while JQ1 inhibits proliferation.

bioRxiv · Dec 10, 2021 · PreprintCancer Biology

Hemangiosarcoma cells induce M2 polarization and PD-L1 expression in macrophages

K. C. M. Gulay, K. Aoshima, N. Maekawa, S. Konnai, A. Kobayashi, T. Kimura

This study identifies ISOS-1 as a syngeneic mouse model for canine hemangiosarcoma and shows that tumor-associated macrophages are M2-polarized and express PD-L1, contributing to immune evasion.

bioRxiv · Aug 1, 2021Cancer Biology

KDM2B promotes cell viability by enhancing DNA damage response in canine hemangiosarcoma

K. C. M. Gulay, K. Aoshima, Y. Shibata, H. Yasui, Q. Yan, A. Kobayashi, T. Kimura

This study shows KDM2B promotes canine hemangiosarcoma cell viability by enhancing DNA damage response and suggests GSK-J4 as a potential therapeutic alternative.

bioRxiv · Nov 17, 2020Cancer Biology

CECR2 Drives Breast Cancer Metastasis by Suppressing Macrophage Inflammatory Responses

M. Zhang, Z. Liu, K. Aoshima, Y. Zhang, Y. An, A. Aoshima, L. H. Chan, S. Lang, H. Sun, Z. Tang, S. Rutter, C. J. Booth, V. Bossuyt, X. Chen, J. Morrow, , Q. Yan

This study identifies CECR2 as a driver of breast cancer metastasis by suppressing macrophage inflammatory responses, offering a therapeutic target for metastatic disease.

bioRxiv · Sep 10, 2020Cancer Biology