Author

J. A. Jimenez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CUT&Tag· 1

Frequent Co-Authors

A. A. Apfelbaum· 2 shared E. R. Lawlor· 2 shared A. A. Mujeeb· 1 shared A. Andjelkovic-Zochowska· 1 shared A. Andren· 1 shared A. Calinescu· 1 shared A. Comba· 1 shared A. Hawkins· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCancer Biology

A. A. Apfelbaum

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

HOXD13 is a direct EWS-FLI1 target and moderates fusion-dependent transcriptional states

A. A. Apfelbaum, F. Wu, A. Hawkins, J. A. Jimenez, S. D. Taylor, E. R. Pfaltzgraff, J. Y. Song, C. Hall, D. M. Wellik, M. Ljungman, S. N. Furlan, R. J. H. Ryan, J. F. Sarthy, E. R. Lawlor

The paper identifies HOXD13 as a direct target of EWS-FLI1 and shows it modulates transcriptional states in Ewing sarcoma by antagonizing EWS-FLI1-dependent gene repression.

bioRxiv · Jan 31, 2022 · PreprintCancer Biology

Systemic delivery of a CXCR4-CXCL12 signaling inhibitor encapsulated in synthetic protein nanoparticles for glioma immunotherapy

M. S. Alghamri, K. Banerjee, A. A. Mujeeb, A. Taher, R. Thalla, B. L. McClellan, M. L. Varela, S. M. Stamatovic, G. Martinez-Revollar, A. Andjelkovic-Zochowska, J. V. Gregory, P. Kadiyala, A. Calinescu, J. A. Jimenez, A. A. Apfelbaum, , M. G. Castro

This paper develops synthetic protein nanoparticles delivering a CXCR4 inhibitor to treat glioma by enhancing immunotherapy and reducing tumor progression.

bioRxiv · Aug 27, 2021 · PreprintCell Biology

The Pancreatic Tumor Microenvironment Compensates for Loss of GOT2

S. A. Kerk, L. Lin, A. L. Myers, Y. Zhang, J. A. Jimenez, P. Sajjakulnukit, B. S. Nelson, B. Chen, A. Robinson, G. Thurston, S. B. Kemp, N. G. Steele, M. T. Hoffman, H.-J. Wen, D. Long, , C. A. Lyssiotis

This study shows that the pancreatic tumor microenvironment compensates for loss of GOT2 by providing pyruvate, maintaining redox homeostasis and tumor growth in vivo.

bioRxiv · Aug 7, 2020Cancer Biology

Drainage of inflammatory macromolecules from brain to periphery targets the liver for macrophage infiltration

L. Yang, J. A. Jimenez, A. M. Earley, V. Hamlin, V. Kwon, C. T. Dixon, C. E. Shiau

This study shows that brain inflammation leads to macrophage infiltration into the liver via the circulation of inflammatory macromolecules, independent of Kupffer cells.

bioRxiv · Jun 18, 2020Immunology