An uncanonical CDK6 activity inhibits cilia function by suppressing axoneme polyglutamylation
K. He, X. Sun, C. Chen, S. Luc, J. Hao, Y. Zhang, Y. Huang, H. Wang, K. Ling, J. Hu
This study identifies CDK6 as a regulator of axoneme polyglutamylation by phosphorylating FIP5, leading to impaired cilia function and ciliopathies, and shows CDK6 inhibitors can restore cilia function.
bioRxiv · Jun 22, 2023 · PreprintCell Biology