Author

G. Williams

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3 Cancer Biology· 2 Biochemistry· 1 Ecology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 6 Assay:bulk RNA-seq· 4 Research Focus:differential expression· 4 Research Focus:drug response / drug discovery· 4 Research Focus:cell type annotation· 3 Research Focus:gene regulatory network inference· 2 Assay:imaging· 2

Frequent Co-Authors

C. Cano· 2 shared J. Suman· 2 shared K. AboulFotouh· 2 shared K.-M. Hardisty· 2 shared M. Loddo· 2 shared R. O. Williams· 2 shared R. Thatcher· 2 shared Y.-S. Yu· 2 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersPharmacology & Toxicology

C. Cano

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Feasibility of intranasal delivery of thin-film freeze-dried monoclonal antibodies

Y.-S. Yu, H. Xu, K. AboulFotouh, G. Williams, J. Suman, S. Sahakijpijarn, C. Cano, Z. Warnken, K. C.- W. Wu, R. O. Williams, Z. Cui

This paper demonstrates the feasibility of intranasally delivering monoclonal antibodies as dry powders using thin-film freeze-drying and the UDS Powder Nasal Spray System.

bioRxiv · Oct 23, 2023 · PreprintPharmacology & Toxicology

SARS-CoV-2 Spike Protein Reduces Burst Activities in Neurons Measured by Micro-Electrode Arrays

M. Salvador, N. Tseng, C. Park, G. Williams, A. Vethan, G. Thomas, J. Baker, J. Hemry, E. Hammond, P. Freeburg, G.-W. Chou, N. Taylor, Y.-F. Lu

This study shows that SARS-CoV-2 S1 protein reduces neuronal burst activity in vitro, while S2 does not, and this effect is blocked by an anti-S1 antibody.

bioRxiv · Apr 24, 2023Microbiology

Feasibility of intranasal delivery of thin-film freeze-dried, mucoadhesive AS01B-adjuvanted vaccine powders

Y.-S. Yu, K. AboulFotouh, G. Williams, J. Suman, C. Cano, Z. N. Warnken, R. O. Williams, Z. Cui

This study demonstrates that thin-film freeze-drying can convert a liquid vaccine into a dry powder with mucoadhesive properties, which can be effectively delivered using a nasal device for intranasal vaccination.

bioRxiv · Nov 1, 2022 · PreprintPharmacology & Toxicology

Cell morphological profiling enables high-throughput screening for PROteolysis TArgeting Chimera (PROTAC) phenotypic signature

K. Moreau, M.-A. Trapotsi, E. Mouchet, G. Williams, T. Monteverde, K. Juhani, R. Turkki, F. Miljkovic, A. Martinsson, L. Mervin, E. Mullers, I. Barrett, O. Engkvist, A. Bender

This study uses cell morphological profiling to identify phenotypic signatures of PROTACs, revealing mitotoxicity that cannot be predicted from individual components.

bioRxiv · Jan 17, 2022Pharmacology & Toxicology

Transcription Profile And Pathway Analysis Of The Endocannabinoid Receptor Inverse Agonist AM630 In The Core And Infiltrative Boundary Of Human Glioblastoma Cells

G. Williams, D. Chambers, R. Rahmam, F. Molina-Holgado

This study compares the transcriptional response of AM630 in GBM core and invasive margin cells, finding distinct gene expression patterns and drug sensitivities.

bioRxiv · Dec 29, 2021Cancer Biology

Transcriptional analysis of peripheral memory T cells reveals Parkinson's disease-specific gene signatures

R. Dhanwani, J. Rodrigues Lima-Junior, A. Sethi, J. Pham, G. Williams, A. Frazier, Y. Xu, A. W. Amara, D. G. Standaert, J. G. Goldman, I. Litvan, R. N. Alcalay, B. Peters, D. Sulzer, C. S. Lindestam Arlehamn, A. Sette

The paper identifies PD-specific gene signatures in peripheral memory T cells by analyzing RNA-seq data from PD patients and healthy controls.

bioRxiv · May 28, 2021Immunology

Utilisation of semiconductor sequencing for detection of actionable fusions in solid tumors

M. Loddo, K.-M. Hardisty, T. Haddow, R. Thatcher, G. Williams

This study demonstrates that semiconductor sequencing can effectively detect actionable fusions in formalin-fixed solid tumor samples, identifying 7.4% of cases with potential targeted therapies.

bioRxiv · Jan 27, 2021 · PreprintCancer Biology

Ecological habitat partitioning and feeding specialisations of coastal minke whales (Balaenoptera acutorostrata) using a designated MPA in northeast Scotland

K. P. Robinson, C. C. G. Bamford, W. J. Brown, R. M. Culloch, C. J. Dolan, R. Hall, G. Russell, T. Sidiropoulos, E. Spinou, T. M. C. Sim, E. Stroud, G. Williams, G. N. Haskins

This study examines the distribution and feeding behaviors of minke whales by age-class in a Marine Protected Area, finding spatial and dietary differences between adults and juveniles.

bioRxiv · Jan 25, 2021 · PreprintEcology

Utilisation of semiconductor sequencing for the detection of predictive biomarkers in glioblastoma

G. Williams, R. Thatcher, K.-M. Hardisty, M. Loddo

This study uses semiconductor sequencing to identify actionable mutations in glioblastoma patients, revealing potential therapeutic targets and linking them to targeted therapies and immunotherapies.

bioRxiv · Jan 11, 2021Pathology

Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein

X. Chen, Y. Ali, C. E. L. Fisher, R. Arribas-Bosacoma, M. B. Rajasekaran, G. Williams, S. Walker, J. R. Booth, J. J. R. Hudson, S. M. Roe, L. H. Pearl, S. E. Ward, F. M. G. Pearl, A. W. Oliver

The paper identifies an allosteric inhibitor of BLM's ATPase-coupled DNA helicase activity and characterizes its mechanism through crystallographic analysis.

bioRxiv · Nov 30, 2020Biochemistry