Author

T. L. Doering

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 10

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:proteomics· 5 Organism:C. elegans· 4 Research Focus:cell type annotation· 4 Organism:fungi (other)· 4 Approach:genetic perturbation / CRISPR· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

E. A. Gaylord· 3 shared D. P. Agustinho· 2 shared G. Chen· 2 shared H. L. Choy· 2 shared L. X. Li· 2 shared A. L. Chang· 1 shared A. S. Ibrahim· 1 shared C. Boone· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersMicrobiology

E. A. Gaylord

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Author profile →

10 papers

Recent·Most cited

Brilacidin, a novel antifungal agent against Cryptococcus neoformans

C. Diehl, C. F. Pinzan, P. A. de Castro, E. Delbaje, L. G. Carnero, E. Sanchez-Leon, K. Bhalla, J. W. Kronstad, D.-g. Kim, T. L. Doering, S. Alkhazraji, N. N. Mishra, A. S. Ibrahim, M. Yoshimura, L. A. V. Isuhuayla, , G. H. Goldman

This paper identifies brilacidin as a novel antifungal agent effective against Cryptococcus neoformans, showing it reduces fungal survival in macrophages and potentiates existing antifungals.

bioRxiv · Apr 10, 2024 · PreprintMicrobiology

Sac1 links phosphoinositide turnover to cryptococcal virulence

E. A. Gaylord, H. L. Choy, G. Chen, S. L. Briner, T. L. Doering

This study identifies Sac1 as a key factor in cryptococcal virulence by linking phosphoinositide turnover to host cell uptake and capsule production through genome-scale screening.

bioRxiv · Jan 18, 2024Microbiology

A novel glycosyltransferase organizes fungal glycogen and cell wall glucans

L. Loza, T. L. Doering

This study identifies two enzymes, Glg1 and Goe1, that link glycogen synthesis to cell wall glucan formation in Cryptococcus neoformans.

bioRxiv · Oct 24, 2023 · PreprintMicrobiology

Unbiased discovery of natural sequence variants that influence fungal virulence

D. P. Agustinho, H. L. Brown, G. Chen, M. Brent, T. L. Doering

The paper identifies natural sequence variants affecting fungal virulence in Cryptococcus neoformans using unbiased genetic methods and validates findings in a mouse model.

bioRxiv · Apr 23, 2023Microbiology

Ergosterol distribution controls surface structure formation and fungal pathogenicity

H. L. Choy, E. A. Gaylord, T. L. Doering

This study identifies Ysp2 as a retrograde sterol transporter in Cryptococcus neoformans, showing its role in ergosterol distribution, cell wall formation, and virulence.

bioRxiv · Feb 17, 2023Microbiology

The ER protein translocation channel subunit Sbh1 controls virulence of Cryptococcus neoformans

F. H. Santiago-Tirado, T. Hurtaux, J. Geddes-McAlister, D. Nguyen, V. Helms, T. L. Doering, K. Romisch

This paper shows that Sbh1 in Cryptococcus neoformans regulates virulence by controlling the secretion of virulence factors through the secretory pathway.

bioRxiv · Jun 1, 2022 · PreprintMicrobiology

Short homology-directed repair using optimized Cas9 in the pathogen Cryptococcus neoformans enables rapid gene deletion and tagging

M. Y. Huang, M. B. Joshi, M. J. Boucher, S. Lee, L. C. Loza, E. A. Gaylord, T. L. Doering, H. D. Madhani

This paper optimizes Cas9 for Cryptococcus neoformans to enable efficient gene editing with short homology arms.

bioRxiv · Jun 30, 2021Microbiology

The transcription factor Pdr802 regulates Titan cell formation, quorum sensing, and pathogenicity of Cryptococcus neoformans

J. C. V. Reuwsaat, H. Motta, D. P. Agustinho, H. Brown, A. L. Chang, M. R. Brent, L. Kmetzsch, T. L. Doering

bioRxiv · Jun 29, 2020Microbiology

Cryptococcus neoformans evades pulmonary immunity by modulating xylose precursor transport

L. X. Li, C. R. Hole, J. Rangel-Moreno, S. A. Khader, T. L. Doering

This study shows that Cryptococcus neoformans evades pulmonary immunity by modulating xylose precursor transport, leading to altered immune responses and iBALT formation.

bioRxiv · May 11, 2020Microbiology

Hypermutation in Cryptococcus reveals anovel pathway to 5-fluorocytosine (5FC) resistance

R. B. Billmyre, S. Applen Clancey, L. X. Li, T. L. Doering, J. Heitman

The paper identifies a novel pathway to 5-fluorocytosine resistance in Cryptococcus through hypermutation and mutations in the UXS1 gene.

bioRxiv · Oct 10, 2019Microbiology