Author

K. Saijo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Stahl· 2 shared B. Ford· 2 shared D. K. Nomura· 2 shared G. A. Timblin· 2 shared K. M. Tharp· 2 shared A. Dillin· 1 shared A. Dunn· 1 shared A. L. Gunawan· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

A. Stahl

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Coenzyme Q regulates UCP1 expression and thermogenesis through the integrated stress responses

C.-F. Chang, A. L. Gunawan, P.-J. H. Zushin, G. A. Timblin, A. M. Bertholet, B. Wang, K. Saijo, Y. Kirichok, A. Stahl

This study shows that CoQ deficiency in BAT activates the ISR and suppresses UCP1, yet increases whole-body metabolic rates and reduces weight gain on HFD.

bioRxiv · Mar 18, 2022 · PreprintCell Biology

Mitohormesis reprograms macrophage metabolism to enforce tolerance

G. A. Timblin, K. M. Tharp, B. Ford, J. M. Winchester, J. Wang, S. Zhu, R. I. Khan, S. K. Louie, A. T. Iavarone, J. ten Hoeve, D. K. Nomura, A. Stahl, K. Saijo

This paper shows that mitochondrial stress from mtROS and mtRES triggers mitohormesis in macrophages, leading to tolerance by suppressing proinflammatory gene transcription.

bioRxiv · Oct 20, 2020Immunology

Adhesion-mediated mechanosignaling forces mitohormesis

K. M. Tharp, R. Higuchi-Sanabria, G. Timblin, B. Ford, C. Garzon-Coral, C. Schneider, J. M. Muncie, C. Stashko, J. Daniele, A. S. Moore, P. Frankino, S. Manoli, H. Shao, A. L. Richards, K.-H. Chen, , V. M. Weaver

The paper shows that adhesion-mediated mechanosignaling activates a mitochondrial stress response through SLC9A1 and HSF1, altering mitochondrial function in aging and cancer.

bioRxiv · Mar 6, 2020Cell Biology