K.-H. Chow

Mice with a humanized immune system are resilient to transplantation of human microbiota

This study shows that humanized mice with engrafted human immune cells can resist human gut microbes, but microbial communities differ from those in non-humanized mice.

FGFR inhibitor mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance

The paper shows that FGFR inhibitors cause SWI/SNF complex dismissal from YAP-dependent enhancers, leading to adaptive resistance in TNBC through epigenetic and metabolic changes.

Functional drug susceptibility testing based on biophysical measurements predicts patient outcome in glioblastoma patient-derived neurosphere models

Using biophysical assays on glioblastoma patient-derived neurosphere models, the study finds that ex vivo drug susceptibility testing predicts patient survival with similar accuracy to MGMT promoter methylation.