ImmunologybioRxiv
ROS-dependent palmitoylation is an obligate licensing modification for GSDMD pore formation
G. Du, L. B. Healy, L. David…·H. Wu
This study identifies palmitoylation as a required modification for GSDMD pore formation, showing that ROS induces this modification and is essential for membrane translocation and cell death.
DOI 10.1038/s41586-024-07373-5