G. Du

Discovery of Potent Degraders of the Dengue Virus Envelope Protein

This study develops small molecule degraders of the dengue virus envelope protein, demonstrating their ability to induce proteosome-mediated degradation and providing a foundation for antiviral drug development.

Circular RNA HMGCS1 sponges miR4521 to aggravate type 2 diabetes-induced vascular endothelial dysfunction

This study identifies circHMGCS1 as a regulator of vascular endothelial dysfunction in diabetes by sponging miR4521, leading to impaired nitric oxide production and increased oxidative stress.

Cooperative progression of colitis and leukemia modulated by clonal hematopoiesis via PTX3/IL-1β; pro-inflammatory signaling

This study shows that clonal hematopoiesis driven by TET2 mutations interacts with inflammatory signals like PTX3/IL-1β to promote colitis and leukemia through a gut-bone marrow axis.

ROS-dependent palmitoylation is an obligate licensing modification for GSDMD pore formation

This study identifies palmitoylation as a required modification for GSDMD pore formation, showing that ROS induces this modification and is essential for membrane translocation and cell death.

Transcription factor-like 5 is a potential DNA/RNA-binding protein essential for maintaining male fertility in mice.Running title: Tcfl5 is haploinsufficient in vivo

This study identifies Tcfl5 as a testis-specific protein essential for male fertility, showing that heterozygous mice are infertile and exhibit abnormalities in spermatids and spermatozoa.

A framework for predicting potential host ranges of pathogenic viruses based on receptor ortholog analysis

The paper introduces REPOST, a framework predicting potential virus hosts by analyzing receptor orthologs, achieving 95.74% accuracy for SARS-CoV-2.

Identification of NAD-dependent xylitol dehydrogenase from Gluconobacter oxydans WSH-003

This paper identifies and characterizes an NAD-dependent xylitol dehydrogenase from Gluconobacter oxydans WSH-003, showing high activity for D-sorbitol to D-fructose conversion and distinct optimal conditions.

Bile acids target proteolipid nano-assemblies of EGFR and phosphatidic acid in the plasma membrane for stimulation of MAPK signaling

This study shows bile acids like DCA alter lipid nano-assemblies in the plasma membrane, promoting EGFR clustering and MAPK signaling in Caco-2 cells and human intestinal enteroids.

Compromised External Validity: Federally Produced Cannabis Does Not Reflect Legal Markets

This study compares federally produced Cannabis with state-legal market Cannabis, finding federal samples have less variety and lower cannabinoid concentrations, limiting research validity.