C. Walker

Plasmodesmal closure elicits stress responses

This study shows that plasmodesmal closure triggers stress responses in plants, including gene expression changes and altered susceptibility to pathogens.

Liquid-like condensates that bind actin drive filament polymerization and bundling

The paper shows that actin-binding proteins forming liquid-like condensates can polymerize and bundle actin filaments, expanding the known set of proteins capable of this function.

The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A

This study identifies the αC-β4 loop as a key regulator of allosteric cooperativity between nucleotide and substrate in PKA-C through simulations and mutagenesis experiments.

ROS-dependent palmitoylation is an obligate licensing modification for GSDMD pore formation

This study identifies palmitoylation as a required modification for GSDMD pore formation, showing that ROS induces this modification and is essential for membrane translocation and cell death.

Chronic inflammation suppresses del(5q)-like MDS HSCs via p53

This study shows chronic inflammation impairs del(5q)-like MDS HSPCs by activating p53, leading to reduced quiescence and disease severity, which may drive p53 mutations in myeloid malignancies.

Per-Pathogen Virulence of HIV-1 subtypes A, C and D

The paper compares the per-pathogen virulence of HIV-1 subtypes A, C, and D using clinical data and finds subtype C has significantly higher virulence than subtype A.

Evaluation of a polymeric composite bone filler scaffold for local antibiotic delivery to prevent Staphylococcus aureus infection in a contaminated bone defect

This paper evaluates a bone filler scaffold for local antibiotic delivery to prevent Staphylococcus aureus infection in contaminated bone defects, showing effective bacterial eradication and no adverse effects on osteogenic properties.

Molecular determinants for α-tubulin methylation by SETD2

This study identifies the molecular mechanisms by which SETD2 methylates α-tubulin, revealing distinct substrate recognition and catalytic requirements for tubulin versus histone methylation.

A phylodynamic workflow to rapidly gain insights into the dispersal history and dynamics of SARS-CoV-2 lineages

This paper introduces a phylodynamic workflow to analyze SARS-CoV-2 lineage dispersal, showing external introductions were key in Belgium and lockdowns had limited impact on transmission.

Understanding and eliminating the detrimental effect of endogenous thiamine auxotrophy on metabolism of the oleaginous yeast Yarrowia lipolytica

This study identifies the genetic basis of thiamine auxotrophy in Yarrowia lipolytica and engineers a thiamine-prototrophic strain with enhanced lipid production.

The 14q32.31 DLK1-DIO3 MIR300 tumor suppressor promotes leukemogenesis by inducing cancer stem cell quiescence and inhibiting NK cell anti-cancer immunity.

Exceptional Solvent Tolerance in Yarrowia lipolytica Is Enhanced by Sterols

This study engineered Yarrowia lipolytica to tolerate high concentrations of ionic liquids by enhancing sterol content in cell membranes, enabling robust growth in up to 18% [EMIM][OAc].