L. Collinson

A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite

This study identifies PfGDPD as a choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in Plasmodium falciparum.

Crosshair, semi-automated targeting for electron microscopy with a motorised ultramicrotome

The paper introduces a semi-automated workflow for targeting regions of interest in resin-embedded samples using a motorised ultramicrotome and an open-source Fiji plugin called Crosshair.

LAP1 regulates nuclear plasticity to enable constrained migration

The paper identifies LAP1 as a regulator of nuclear plasticity that enables constrained migration in melanoma cells.

The Aspartyl Protease Ddi1 Is Essential for Erythrocyte Invasion by the Malaria Parasite

This study shows that PfDdi1 proteolytic activity is essential for Plasmodium falciparum erythrocyte invasion and identifies it as a potential antimalarial target.

Adipose Triglyceride Lipase protects the endocytosis of renal cells on a high fat diet in Drosophila

This study shows that adipose triglyceride lipase (ATGL) in Drosophila nephrocytes protects against high-fat diet-induced renal endocytosis defects by lipid droplet lipolysis and mitochondrial pathways.

A lipocalin mediates unidirectional haem biomineralization in malaria parasites

This study identifies PV5, a lipocalin-like protein, as critical for controlling haem crystallization into haemozoin in malaria parasites, with implications for drug development.

Engineering transplantable jejunal mucosal grafts using primary patient-derived organoids from children with intestinal failure

This study develops a method to create transplantable jejunal mucosal grafts using patient-derived organoids and decellularized scaffolds, demonstrating functional grafts in vitro and in vivo.

In vivo control of Toxoplasma gondii by zebrafish macrophages

This study uses a zebrafish model to show that macrophages control Toxoplasma gondii infection in vivo, with type II and III strains having higher infectious burdens than type I.

Mycobacterium tuberculosis cording in the cytosol of live lymphatic endothelial cells

This study shows that Mycobacterium tuberculosis forms intracellular cords in human lymphatic endothelial cells, evading xenophagy via the ESX-1 system and PDIM lipid.

Differential requirements of cyclase associated protein (CAP) for actin turnover during the lytic cycle of Toxoplasma gondii

This study investigates the role of cyclase-associated protein (CAP) in actin turnover during the Toxoplasma gondii lytic cycle, finding differential requirements for CAP in cell-cell communication and residual body formation.