W. Guan

Bacterial diversity and composition on the rinds of specific melon cultivars and hybrids from across different growing regions in the United States

This study characterizes bacterial diversity on melon rinds across US regions and identifies regional influences on microbiome composition.

STAMP-Based Digital CRISPR-Cas13a (STAMP-dCRISPR) for Amplification-Free Quantification of HIV-1 Plasma Viral Load

This paper develops STAMP-dCRISPR, a digital CRISPR-Cas13a method for amplification-free HIV-1 viral load quantification, showing high accuracy and speed comparable to RT-qPCR.

Crosshair, semi-automated targeting for electron microscopy with a motorised ultramicrotome

The paper introduces a semi-automated workflow for targeting regions of interest in resin-embedded samples using a motorised ultramicrotome and an open-source Fiji plugin called Crosshair.

Integrated platform for multi-scale molecular imaging and phenotyping of the human brain

The paper develops a platform for multi-scale molecular imaging and phenotyping of the human brain, integrating novel tools for tissue processing, imaging, and computational reconstruction.

Antibody Cocktail Exhibits Broad Neutralization against SARS-CoV-2 and SARS-CoV-2 variants

This study identifies two antibodies, F61 and H121, that neutralize SARS-CoV-2 and its variants, including B.1.1.7 and B.1.351, by targeting distinct epitopes on the RBD.

A human antibody with blocking activity to RBD proteins of multiple SARS-CoV-2 variants including B.1.351 showed potent prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus macaques

Molecular Typing of Human Respiratory Adenoviruses with Universal PCR and Sequencing Primers for Three Major Capsid Genes: Penton base, Hexon, and Fiber

The paper presents a molecular typing method for respiratory adenoviruses using universal PCR and sequencing primers for three capsid genes, enabling rapid identification of HAdV types and recombinants in clinical samples.

Ultrafast immunostaining of organ-scale tissues for scalable proteomic phenotyping

The paper introduces eFLASH, a method for rapid, uniform labeling of organ-scale tissues, enabling scalable proteomic phenotyping across species and tissues.