S. Amin

Metabolic engineering and late-stage functionalization expand the chemical space of the antimalarial premarineosin A

This study uses metabolic engineering and late-stage functionalization to expand the chemical diversity of the antimalarial compound premarineosin A, identifying potent analogs.

Single-cell immune multi-omics and repertoire analyses in pancreatic ductal adenocarcinoma reveal differential immunosuppressive mechanisms within different tumour microenvironments

The paper analyzes single-cell immune multi-omics data from PDAC to identify differential immunosuppressive mechanisms in distinct tumour microenvironments.

HDX-MS reveals concealed conformations of ISWI during different stages of nucleosome sliding

This study uses HDX-MS to reveal conformational changes in ISWI during nucleosome sliding, showing it transitions from a closed to open state and undergoes structural changes during the sliding step.

Uracil-DNA glycosylase efficiency is modulated by substrate rigidity

This study shows that uracil-DNA glycosylase efficiency is determined by substrate flexibility, with more flexible DNA sequences showing higher enzyme activity.

mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits comparable B cell expansion, neutralizing antibodies and protection against Omicron

This study compares B cell responses and protection against Omicron after boosting vaccinated macaques with mRNA-1273 or mRNA-Omicron vaccines, finding comparable immunity and protection.

A single, improbable B cell receptor mutation confers potent neutralization against cytomegalovirus

mTORC2 contributes to murine systemic autoimmunity

This study shows mTORC2 promotes Tfh differentiation and disrupts Treg homeostasis, contributing to systemic autoimmunity, and suggests mTORC2 as a potential therapeutic target.

Response of Prosopis farcta to copper and cadmium stress and potential for accumulation and translocation of these heavy metals

This study evaluates the effects of copper and cadmium stress on Prosopis farcta, finding that Cd is more toxic and more efficiently translocated from roots to shoots than Cu.

Bivalent and Broad Chromatin Domains Regulate Pro-metastatic Drivers in Melanoma

The paper identifies bivalent chromatin states and broad H3K4me3 domains associated with pro-metastatic drivers in melanoma using ChIP-sequencing data from tumor samples and cell lines.

Super-enhancer impairment is a link between MLL4 inactivated lung tumors and their vulnerability to glycolysis pathway inhibition

The paper shows that MLL4 loss in lung cancer promotes glycolysis and that inhibiting glycolysis selectively targets MLL4-mutant lung tumors.

Enhancer Reprogramming Confers Dependence on Glycolysis and IGF signaling in KMT2D Mutant Melanoma

This study identifies KMT2D as a tumor suppressor in melanoma, showing its loss leads to metabolic reprogramming toward glycolysis and dependence on IGF signaling, suggesting therapeutic targeting of these pathways.

TumorFusions: an integrative resource for reporting cancer-associated transcript fusions in 33 tumor types

The paper reports cancer-associated transcript fusions in 33 tumor types using TCGA data and provides a resource for accessing the results.