Author

V. Penna

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:cell-cell communication· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2

Frequent Co-Authors

K. Lavine· 3 shared A. L. Bredemeyer· 2 shared A. L. Koenig· 2 shared D. Kreisel· 2 shared F. F. Kadyrov· 2 shared J. M. Amrute· 2 shared K. J. Lavine· 2 shared L. Lai· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersImmunology

K. Lavine

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Inhibition of Soluble Epoxide Hydrolase Reduces Inflammation and Myocardial Injury in Arrhythmogenic Cardiomyopathy

D. Panigrahy, A. Kelly, W. Wang, J. Yang, S. H. Hwang, M. Gillespie, I. Howard, C. Bueno-Beti, A. Asimaki, V. Penna, K. Lavine, M. Edin, D. Zeldin, B. Hammock, J. Saffitz

This study shows that inhibiting soluble epoxide hydrolase reduces inflammation and myocardial injury in arrhythmogenic cardiomyopathy by increasing pro-resolving lipid mediators.

bioRxiv · Feb 17, 2024Cell Biology

Mechanisms of Innate Immune Injury in Arrhythmogenic Cardiomyopathy

S. P. Chelko, V. Penna, M. Engel, M. Landim-Vieira, E. N. Cannon, K. Lavine, J. E. Saffitz

This study identifies NFκB signaling in cardiac myocytes as a driver of myocardial injury and arrhythmias in a mouse model of arrhythmogenic cardiomyopathy.

bioRxiv · Jul 12, 2023 · PreprintImmunology

Targeting the Immune-Fibrosis Axis in Myocardial Infarction and Heart Failure

J. M. Amrute, X. Luo, V. Penna, A. Bredemeyer, T. Yamawaki, G. S. Heo, S. Shi, A. L. Koenig, S. Yang, F. F. Kadyrov, C. Jones, C. Kuppe, B. Kopecky, S. Hayat, P. Ma, , K. Lavine

The paper identifies a fibroblast trajectory associated with cardiac fibrosis and shows that macrophage-fibroblast crosstalk via IL-1β signaling drives fibrosis.

bioRxiv · Oct 17, 2022 · PreprintImmunology

Hypoxia Sensing in Resident Cardiac Macrophages Regulates Monocyte Fate Specification following Ischemic Heart Injury

F. F. Kadyrov, A. L. Koenig, J. M. Amrute, H. Dun, W. Li, C. J. Weinheimer, J. M. Nigro, A. Kovacs, A. L. Bredemeyer, L. Lai, B. J. Kopecky, V. Penna, D. Kreisel, K. J. Lavine

This study shows that hypoxia sensing in cardiac macrophages influences monocyte differentiation into inflammatory states after heart injury.

bioRxiv · Aug 4, 2022 · PreprintImmunology

SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis

A. L. Bailey, O. Dmytrenko, L. Greenberg, A. L. Bredemeyer, P. Ma, J. Liu, V. Penna, L. Lai, E. S. Winkler, S. Sviben, E. Brooks, A. P. Nair, K. A. Heck, A. S. Rali, L. Simpson, , K. J. Lavine

This study shows SARS-CoV-2 infects human engineered heart tissues, causing myocarditis-like features, and identifies ACE2 and proteases as entry factors.

bioRxiv · Nov 4, 2020Immunology