Tuning the course of evolution on the biophysical fitness landscape of an RNA virus
A. Rotem, A. Serohijos, C. Chang, J. Wolfe, A. Fischer, T. Mehoke, H. Zhang, Y. Tao, L. Ung, J.-M. Choi, A. Kolawole, S. Koehler, S. Wu, P. Thielen, N. Cui, , E. Shakhnovich
This study predicts the evolutionary pathway of norovirus escaping antibodies using a biophysical fitness model, validated by experimental evolution in bulk culture and microfluidics.
bioRxiv · Dec 8, 2016Evolutionary Biology