J. Wolfe

Multiple mechanisms contribute to isolation-by-environment in the redheaded pine sawfly, Neodiprion lecontei

This study identifies multiple mechanisms contributing to isolation-by-environment in the redheaded pine sawfly by analyzing host-associated differentiation and ecological barriers.

Measurement of plant water status via static uniaxial compression of the leaf lamina

The paper develops a method to measure plant water status using leaf compression tests, finding strong correlations between mechanical stress/strain and turgor pressure/water content.

Immortalization and Functional Screening of Natively Paired Human T Cell Receptor Repertoires

The paper develops a high-throughput method to functionally evaluate natively paired human T cell receptors against multiple pMHCs, validated through affinity-based mapping and sequencing.

BTP-7, a novel peptide for therapeutic targeting of malignant brain tumors

This study identifies BTP-7, a peptide that targets dg-Bcan in glioma cells, enhancing drug delivery and survival in tumor-bearing mice.

Deletion of Sphingosine 1-Phosphate Receptor 1 in cardiomyocytes during development leads to abnormal ventricular conduction and fibrosis

This study shows that deleting S1P1 in cardiomyocytes during development causes ventricular hypertrabeculation, fibrosis, and conduction abnormalities, despite preserved systolic function.

Tuning the course of evolution on the biophysical fitness landscape of an RNA virus

This study predicts the evolutionary pathway of norovirus escaping antibodies using a biophysical fitness model, validated by experimental evolution in bulk culture and microfluidics.