Author

P. Thielen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Approach:biophysical modeling· 1 Approach:experimental assay· 1 Research Focus:variant calling· 1

Frequent Co-Authors

T. Mehoke· 3 shared A. Pekosz· 2 shared H. Liu· 2 shared J. Evans· 2 shared K. Shaw-Saliba· 2 shared M. Lewis· 2 shared R. Rothman· 2 shared A. Dugas· 1 shared

Activity by Year

2016-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersMicrobiology

T. Mehoke

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Identification of H3N2 NA and PB1-F2 genetic variants and their association with disease symptoms in the 2014-15 influenza season

D. Blumenkrantz, T. Mehoke, J. Hardick, K. Shaw-Saliba, H. Powell, N. Wohlgemuth, H. Liu, E. Macias, J. Evans, M. Lewis, R. Medina, L. M. Sauer, A. Dugas, A. DuVal, A. P. Lane, , A. Pekosz

The paper identifies H3N2 NA and PB1-F2 genetic variants and links their presence to increased cough and shortness of breath in patients during the 2014-15 influenza season.

bioRxiv · Feb 20, 2020Microbiology

Differential Disease Severity and Whole Genome Sequence Analysis for Human Influenza A/H1N1pdm Virus in 2015-2016 Influenza Season

H. Liu, Y.-N. Gong, K. Shaw-Saliba, T. Mehoke, J. Evans, Z.-Y. Liu, M. Lewis, L. Sauer, P. Thielen, R. Rothman, K.-F. Chen, A. Pekosz

The paper analyzes whole genome sequences of H1N1pdm viruses from 2015-2016 to compare disease severity between Baltimore and Taiwan, finding 6B.2 viruses associated with more severe symptoms in Taiwan.

bioRxiv · Feb 20, 2020 · PreprintMicrobiology

Tuning the course of evolution on the biophysical fitness landscape of an RNA virus

A. Rotem, A. Serohijos, C. Chang, J. Wolfe, A. Fischer, T. Mehoke, H. Zhang, Y. Tao, L. Ung, J.-M. Choi, A. Kolawole, S. Koehler, S. Wu, P. Thielen, N. Cui, , E. Shakhnovich

This study predicts the evolutionary pathway of norovirus escaping antibodies using a biophysical fitness model, validated by experimental evolution in bulk culture and microfluidics.

bioRxiv · Dec 8, 2016Evolutionary Biology