Author

M. A. Digman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:Bayesian inference· 1 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

A. E. Y. T. Lefebvre· 2 shared E. Gratton· 2 shared A. Sohrabi· 1 shared A. Vallmitjana· 1 shared B. Shi· 1 shared D. A. Lawson· 1 shared D. Ma· 1 shared F. Digman· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCancer Biology

A. E. Y. T. Lefebvre

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Microenvironmental Stiffness Induces Metabolic Reprogramming in Glioblastoma

A. Sohrabi, A. E. Y. T. Lefebvre, M. J. Harrison, M. C. Condro, T. M. Sanazzaro, G. Safarians, I. Solomon, S. Bastola, S. Kordbacheh, N. Toh, H. I. Kornblum, M. A. Digman, S. K. Seidlits

This study shows that a softer matrix microenvironment induces glioblastoma cells to shift toward glycolysis, increasing migration and decreasing proliferation.

bioRxiv · Jul 3, 2023Cancer Biology

Fluorescence Lifetime: Beating the IRF and interpulse window

M. Fazel, A. Vallmitjana, L. Scipioni, E. Gratton, M. A. Digman, S. Presse

This paper introduces BNP-LA, a Bayesian nonparametric method for analyzing fluorescence lifetime data with arbitrary lifetimes, and demonstrates its effectiveness using synthetic and experimental data.

bioRxiv · Sep 8, 2022Biophysics

Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis

D. Ma, G. A. Hernandez, A. E. Y. T. Lefebvre, H. Alshetaiwi, K. Blake, K. R. Dave, M. Rauf, J. W. Williams, R. T. Davis, K. T. Evans, M. Y. G. Masoud, R. Lee, R. A. Edwards, M. A. Digman, K. Kessenbrock, D. A. Lawson

This paper develops a 3D tumor sphere culture-transplant system to study human breast cancer metastasis using patient-derived xenografts and validates its utility for functional metastasis assays.

bioRxiv · Jun 25, 2020 · PreprintCancer Biology

Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis

W. Li, J. Hu, B. Shi, F. Digman, M. A. Digman, E. Gratton, H. Jiang

This study shows that AKAP95 protein condensates regulate splicing and tumorigenesis through their biophysical properties.

bioRxiv · Jun 9, 2020Biochemistry

Restoring p53 Function and Silencing REV3L Suppresses the Cancerous Metabolic Phenotype in Cisplatin Treated Human Non-Small Lung Carcinoma Cells

L. Kong, M. M. Murata, M. A. Digman

This study shows that restoring p53 and silencing REV3L reduces cancerous metabolic traits and increases cell death in cisplatin-treated lung cancer cells.

bioRxiv · Oct 10, 2017Cancer Biology