Author

M. A. Fini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Saga-Kamo· 1 shared A. Shindo· 1 shared D. Bratton· 1 shared D. Irwin· 1 shared E. Gerasimovskaya· 1 shared H. Akazawa· 1 shared H. Kadowaki· 1 shared H. Toko· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperPathology

A. Saga-Kamo

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Macrophage Xanthine Oxidoreductase Links LPS Induced Lung Inflammatory Injury to NLRP3 Inflammasome Expression and Mitochondrial Respiration

M. A. Fini, J. A. Monks, M. Li, E. Gerasimovskaya, P. Paucek, K. Wang, M. G. Frid, S. C. Pugliese, D. Bratton, Y.-R. Yu, D. Irwin, M. Karin, R. M. Wright, K. R. Stenmark

This study shows that macrophage-specific Xanthine Oxidoreductase (XOR) exacerbates LPS-induced lung injury by promoting NLRP3 inflammasome expression and glycolytic metabolism in inflammatory macrophages.

bioRxiv · Jul 21, 2023 · PreprintImmunology

Aberrant mechanosensitive signaling underlies activation of vascular endothelial xanthine oxidoreductase that promotes aortic aneurysm formation in Marfan syndrome

H. Yagi, H. Akazawa, Q. Liu, K. Yamamoto, K. Nawata, A. Saga-Kamo, M. Umei, H. Kadowaki, R. Matsuoka, A. Shindo, H. Toko, N. Takeda, M. Ando, H. Yamauchi, N. Takeda, , I. Komuro

This study identifies aberrant mechanosensitive signaling in vascular endothelial cells as a driver of xanthine oxidoreductase activation and ROS generation, contributing to aortic aneurysm formation in Marfan syndrome.

bioRxiv · Jan 30, 2022Pathology