Author

N. Takeda

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1 Evolutionary Biology· 1 Immunology· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 6 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

I. Komuro· 3 shared A. Saga-Kamo· 2 shared A. Shindo· 2 shared H. Akazawa· 2 shared H. Kadowaki· 2 shared H. Yagi· 2 shared M. Umei· 2 shared Q. Liu· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCell Biology

I. Komuro

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Cardiomyocyte transcriptomic signatures in response to Trypanosoma cruzi infection underpin Chagas cardiomyopathy progression.

K. Candray, Y. Nakagama, I. Masamichi, S. Nakagama, E. Tshibangu-Kabamba, N. Takeda, Y. Sugiura, Y. Nitahara, Y. Michimuko-Nagahara, N. Kaku, Y. Onizuka, C.-E. Arias, M. Mejia, K. Alas, S. Pena, , Y. Kido

This study identifies transcriptomic changes in cardiomyocytes infected with different T. cruzi strains, highlighting pathways linked to Chagas cardiomyopathy progression.

bioRxiv · Feb 27, 2023 · PreprintCell Biology

Migrating neurons adapt motility modes to brain microenvironments via a mechanosensor, PIEZO1

N. Nakazawa, G. Grenci, Y. Kameo, N. Takeda, T. Sawada, J. Kurisu, Z. Zhejing, T. Adachi, K. Nonomura, M. Kengaku

The paper shows cerebellar granule neurons switch migratory modes in 3D environments using PIEZO1 to generate contractile forces.

bioRxiv · Jan 17, 2023 · PreprintCell Biology

Inverse Agonist Activity of Angiotensin II Receptor Blocker Is Crucial for Prevention of Aortic Aneurysm Formation in Marfan Syndrome

H. Yagi, H. Akazawa, Q. Liu, M. Umei, H. Kadowaki, R. Matsuoka, A. Shindo, S. Okamura, A. Saga-Kamo, N. Takeda, I. Komuro

This study shows that inverse agonist activity of angiotensin II receptor blockers is essential for preventing aortic aneurysm formation in Marfan syndrome mice.

bioRxiv · Dec 21, 2022Pharmacology & Toxicology

PNPO-PLP Axis Senses Prolonged Hypoxia by Regulating Lysosomal Activity

H. Sekine, H. Takeda, A. Kishino, H. Anzawa, T. Isagawa, N. Ota, N. Kato, S. Kimura, Z. Liu, K. Kato, F. Katsuoka, M. Yamamoto, F. Miura, T. Ito, M. Takahashi, , H. Motohashi

The paper identifies the PNPO-PLP axis as a mechanism for sensing prolonged hypoxia by regulating lysosomal activity in macrophages, leading to altered inflammatory responses.

bioRxiv · Oct 28, 2022 · PreprintBiochemistry

Aberrant mechanosensitive signaling underlies activation of vascular endothelial xanthine oxidoreductase that promotes aortic aneurysm formation in Marfan syndrome

H. Yagi, H. Akazawa, Q. Liu, K. Yamamoto, K. Nawata, A. Saga-Kamo, M. Umei, H. Kadowaki, R. Matsuoka, A. Shindo, H. Toko, N. Takeda, M. Ando, H. Yamauchi, N. Takeda, , I. Komuro

This study identifies aberrant mechanosensitive signaling in vascular endothelial cells as a driver of xanthine oxidoreductase activation and ROS generation, contributing to aortic aneurysm formation in Marfan syndrome.

bioRxiv · Jan 30, 2022Pathology

FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis

K.-i. Ishiguro, T. Nobuhiro, K. Takemoto, Y. Horisawa-Takada, R. Shimada, F. Sayoko, N. Tani, N. Takeda, K. Araki

This study shows FBXO47 prevents premature disassembly of the synaptonemal complex in mouse male meiosis, ensuring proper synapsis and crossover formation.

bioRxiv · Nov 17, 2021Cell Biology

Circulating Th17.1 cells as candidate for prediction of therapeutic response to abatacept in patients with rheumatoid arthritis: exploratory research

S. Maeda, S. Osaga, T. Maeda, N. Takeda, S.-y. Tamechika, T. Naniwa, A. Niimi

This study identifies Th17.1 cells as a biomarker predicting response to abatacept in rheumatoid arthritis patients.

bioRxiv · Mar 29, 2019Immunology

A gonad-expressed opsin mediates light-induced spawning in the jellyfish Clytia

G. Quiroga Artigas, P. Lapebie, L. Leclere, N. Takeda, R. Deguchi, G. Jekely, T. Momose, E. Houliston

The paper identifies an opsin in jellyfish that mediates light-induced spawning by triggering neuropeptide hormone release.

bioRxiv · Dec 3, 2017Evolutionary Biology