B. Walker

Human cell surface-AAV interactomes identify LRP6 as blood-brain-barrier transcytosis receptor and immune cytokine IL3 as AAV9 binder

MYC and HSF1 Cooperate to Drive PLK1 inhibitor Sensitivity in High Grade Serous Ovarian Cancer

This study identifies HSF1 and MYC co-amplification in ovarian cancer and shows that targeting PLK1 is more effective in these cells, suggesting a potential precision medicine approach.

Proteins with proximal-distal asymmetries in axoneme localisation control flagellum beat frequency

The paper identifies conserved proximal-distal asymmetries in flagellar axoneme proteins in trypanosomatids and shows their role in controlling flagellum beat frequency.

Plant diversity darkspots for global collection priorities

The paper identifies global plant diversity darkspots with limited species data and prioritizes regions for collection efforts based on environmental and socio-economic scenarios.

Extinction risk predictions for the world's flowering plants to support their conservation

The paper predicts extinction risk for 330,000 angiosperm species using Bayesian Additive Regression Trees, estimating 45.1% are potentially threatened with uncertainty bounds.

Histidine 73 methylation coordinates ????-actin plasticity in response to key environmental factors

This study uses molecular dynamics simulations to show that H73 methylation in β-actin affects nucleotide binding, allosteric pathways, and phosphate release, regulating actin plasticity in response to environmental factors.

Integrative multi-omics identifies high risk Multiple Myeloma segment associated with significant DNA loss and dysregulated DNA repair and cell cycle pathways

The paper identifies a high-risk Multiple Myeloma subgroup using multi-omics data, linking genomic loss to dysregulated DNA repair and cell cycle pathways.

Whole genome sequencing provides evidence of two biologically and clinically distinct entities of asymptomatic monoclonal gammopathies: progressive versus stable myeloma precursor condition

The paper uses whole genome sequencing to identify two distinct myeloma precursor conditions, progressive and stable, based on genomic features.

Low Replication Capacity Virus Is Preferentially Transmitted In Mother-To-Child-Transmission But Not In Adult-To-Adult-Transmission Of HIV-1

The paper compares viral replicative capacity in mother-to-child and adult-to-adult HIV-1 transmission, finding lower replicative capacity in MTCT viruses.