J. Hui

Antimicrobial blue light-bathing therapy for wound infection control

This study introduces a low-irradiance blue light therapy for wound infections, showing it effectively reduces bioburden while being safer than high-irradiance methods.

Two Septin Complexes Mediate Actin Dynamics During Cell Wound Repair

This study identifies two distinct Septin complexes that regulate actin dynamics during cell wound repair in Drosophila.

Scalable Mesenchymal Stem Cells Enrichment from Bone Marrow Aspirate using Deterministic Lateral Displacement (DLD) Microfluidics Sorting

This paper develops a microfluidic method to isolate mesenchymal stem cells from bone marrow aspirate more efficiently than centrifugation.

Genomic and ecologic characteristics of the airway microbial-mucosal complex

The paper characterizes the genomic and ecological features of the airway microbial-mucosal complex, identifying novel bacteria and functional pathways linked to lung diseases.

Cell wound repair requires the coordinated action of linear and branched actin nucleation factors

This study shows that branched actin nucleators scaffold the contractile actomyosin cable during wound repair, and their removal leads to alternative mechanisms of wound closure through linear actin filaments.

Highly efficient, all-organic bioluminescence-photosensitizer conjugate eradicates early-stagetumors and prevents metastasis in mice

This paper develops a bioluminescence-activated PDT system that eradicates tumors and prevents metastasis in mice by using efficient BRET conjugates and membrane-fusion liposomes.

Photoinactivation of catalase sensitizes Candida albicans and Candida auris to ROS-producing agents and immune cells

This study shows that photoinactivating catalase in fungi makes them more susceptible to ROS and immune cells, offering a new approach to treat drug-resistant fungal infections.

Photoinactivation of Catalase Sensitizes Wide-Ranging Bacteria to ROS-Producing Agents and Immune Cells

This study shows that blue light inactivates catalase in bacteria, making them vulnerable to ROS and immune cells, and validates this in a mouse model.

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball patterned arrays

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

Granadaene Photobleaching Reduces the Virulence and Increases Antimicrobial Susceptibility of Streptococcus agalactiae

This study shows that photobleaching granadaene in Streptococcus agalactiae reduces its virulence and increases antimicrobial susceptibility to antibiotics and macrophage killing.

Millipede genomes reveal unique adaptation of genes and microRNAs during myriapod evolution

This paper sequenced two millipede genomes, revealing unique genomic features, defense systems, and microRNA regulation mechanisms in myriapods.

Photo-Disassembly of Membrane Microdomains Revives Conventional Antibiotics against MRSA

This study uses photo-disassembly of membrane microdomains to restore antibiotic susceptibility in MRSA, enabling conventional antibiotics to inhibit resistance development.

Reference intervals of spot urine copper excretion in preschool children and potential application in pre-symptomatic screening of Wilson’s disease

The paper defines reference ranges for spot urine copper excretion in preschool children and identifies optimal cutoff values for pre-symptomatic Wilson’s disease screening.

Distinctive airway microbial ecology of smokers and asthmatics

The paper examines airway microbial communities in smokers and asthmatics, finding smoking reduces diversity and alters bacterial networks, while asthma shows more targeted microbial changes.