Author

M. Jacobson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1 Assay:proteomics· 1 Approach:statistical model· 1 Organism:yeast· 1

Frequent Co-Authors

A. Jennings· 1 shared A. Sil· 1 shared C. J. Kirk· 1 shared C. Kalyanaraman· 1 shared C. Rivera· 1 shared D. G. Ruiz· 1 shared D. McMinn· 1 shared D. Mullins· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

A. Jennings

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Signal peptide mimicry primes Sec61 for client-selective inhibition

S. Rehan, D. Tranter, P. P. Sharp, E. Lowe, J. Anderl, T. Muchamuel, V. Abrishami, S. Kuivanen, N. Wenzell, A. Jennings, C. Kalyanaraman, G. B. Craven, T. Strandin, M. Javanainen, O. Vapalahti, , V. Paavilainen

This study describes KZR-8445, a cyclic depsipeptide that selectively inhibits Sec61-mediated protein biogenesis by mimicking signal peptides, showing efficacy in a rheumatoid arthritis model.

bioRxiv · Jul 3, 2022Biochemistry

Protomer alignment modulates specificity of RNA substrate recognition by Ire1

W. Li, K. Crotty, D. G. Ruiz, M. Voorhies, C. Rivera, A. Sil, D. Mullins, M. Jacobson, J. Peschek, P. Walter

The paper shows that changing two amino acids in S. cerevisiae Ire1 to their S. pombe counterparts makes it promiscuous, revealing that protomer alignment modulates RNA substrate specificity.

eLife · Apr 27, 2021Peer-reviewedBiochemistry