A. Sil

Optimizing in vitro spherulation cues in the fungal pathogen Coccidioides

This study optimizes in vitro spherulation in Coccidioides by adjusting culture conditions, media composition, and arthroconidium preparation to enhance spherule growth and endospore release.

Recyclable CRISPR/Cas9 mediated gene disruption and deletions in Histoplasma

This paper develops a CRISPR/Cas9 system for efficient targeted gene disruption in Histoplasma, enabling high-efficiency mutagenesis and deletion of specific genes.

Chemical stimuli override a temperature-dependent morphological program by reprogramming the transcriptome of a fungal pathogen.

This study identifies transcription factors that reprogram the transcriptome of Histoplasma to induce hyphal growth at 37°C, revealing a regulatory circuit involving STU1, FBC1, and PAC2.

How stra(i)nge are your controls? A comparative analysis of metabolic phenotypes in commonly used C57 substrains

This study compares metabolic phenotypes across five C57BL/6 substrains from two vendors, revealing vendor- and sex-dependent differences in glucose regulation and insulin signaling.

Incorporating fire-smartness into agricultural policies minimises suppression costs and ecosystem services damages from wildfires

This paper evaluates land-use policies to minimize wildfire suppression costs and ecosystem service damages by combining scenario analysis, fire modeling, and economic tools in a mountainous region of the Iberian Peninsula.

NF-κB inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids

The paper uses ACE2-overexpressing airway organoids to show NF-κB inhibitor alpha is upregulated during SARS-CoV-2 infection and its reduced function increases viral infection.

A Legionella toxin mimics tRNA and glycosylates the translation machinery to trigger a ribotoxic stress response.

This paper identifies SidI, a Legionella toxin that mimics tRNA, glycosylates the translation machinery, and triggers a ribotoxic stress response leading to cell death.

Lineage-specific genes are clustered with allorecognition loci and respond to GxE factors regulating the switch from asexual to sexual reproduction in Neurospora

The paper identifies lineage-specific genes (LSGs) in Neurospora crassa that cluster with allorecognition loci and respond to environmental factors regulating the switch from asexual to sexual reproduction.

Immediate myeloid depot for SARS-CoV-2 in the human lung

The paper investigates early SARS-CoV-2 infection in human lung myeloid cells, finding rapid viral tropism, ACE2 dependence, and poor interferon induction, suggesting a myeloid depot for viral persistence.

Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages

This study uses CRISPR screening to identify C3aR as critical for macrophage capture of fungi, revealing a novel role in fungal pathogen recognition.

The ESX-1 secretion system senses bacterial contact and prepares mycobacteria for environmental adaptation

The paper shows the ESX-1 system in mycobacteria senses bacterial contact and environmental nitrogen levels, regulating secretion and adaptation.

Cbp1, a rapidly evolving fungal virulence factor, forms an effector complex that drives macrophage lysis

This paper identifies Cbp1 as a rapidly evolving fungal virulence factor that localizes to the host cell cytosol and forms a complex to drive macrophage lysis.

PEERS - an open science "Platform for the Exchange of Experimental Research Standards" in biomedicine

PEERS provides an open platform to help scientists identify and rate critical experimental factors for reproducible and robust biomedical research.

The WOPR family protein Ryp1 is a key regulator of gene expression, development, and virulence in the thermally dimorphic fungal pathogen Coccidioides posadasii

This study identifies Ryp1 as a key transcription factor regulating spherule formation and virulence in Coccidioides posadasii through transcriptional profiling and mutant analysis.

Chromosome-level genome assembly of a human fungal pathogen reveals synteny among geographically distinct species

This study presents chromosome-level genome assemblies of five Histoplasma strains, revealing synteny and gene expression patterns across geographically distinct isolates.

SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator

The paper identifies TSPAN8 as a novel mediator of SARS-CoV-2 infection in lung organoids, showing its correlation with infection rates and susceptibility to blocking antibodies.

Protomer alignment modulates specificity of RNA substrate recognition by Ire1

The paper shows that changing two amino acids in S. cerevisiae Ire1 to their S. pombe counterparts makes it promiscuous, revealing that protomer alignment modulates RNA substrate specificity.

Recurrent loss of abaA, a master regulator of asexual development in filamentous fungi, correlates with changes in genomic and morphological traits

The paper investigates the loss of abaA, a master regulator of asexual development in fungi, and shows its correlation with morphological changes in asexual fruiting bodies across multiple fungal lineages.

Opposing signaling pathways regulate morphology in response to temperature in the fungal pathogen Histoplasma capsulatum

This study identifies temperature-responsive regulons in Histoplasma capsulatum that regulate morphology and gene expression in response to temperature, revealing opposing signaling pathways that control hyphal and yeast forms.