Reprogramming of 3D chromatin domains by antagonizing the β-catenin/CBP interaction attenuates insulin signaling in pancreatic cancer
Y. Zhou, T. Li, Z. He, L. Choppavarapu, X. Hu, G. Leone, M. Kahn, V. X. Jin
This study shows that inhibiting β-catenin/CBP interaction with ICG-001 alters 3D chromatin structure in pancreatic cancer, affecting insulin signaling and promoting tumor growth.
bioRxiv · Nov 10, 2023Cancer Biology