Author

M. Kloos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein folding & dynamics· 3 Assay:structural biology· 3 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. GoreliD· 2 shared C. Kim· 2 shared F. KouaiD· 2 shared G. Mills· 2 shared G. Schiro· 2 shared H. Kirkwood· 2 shared J. Valerio· 2 shared K. Doerner· 2 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiophysics

A. GorelORCID

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Author profile →

5 papers

Recent·Most cited

Mix-and-extrude: high-viscosity sample injection towards time-resolved protein crystallography

M. Vakili, H. Han, C. Schmidt, A. Wrona, M. Kloos, I. de Diego, K. Dorner, T. Geng, C. Kim, F. Koua, D. Melo, M. Rappas, A. Round, E. Round, M. Sikorski, , J. Schulz

This paper introduces a mix-and-extrude method for time-resolved protein crystallography using 3D printed microchannels to study ligand-induced reactions in viscous media.

bioRxiv · Nov 23, 2022Biochemistry

Influence of pump laser fluence on ultrafast structural changes in myoglobin

T. R. M. Barends, S. Bhattacharyya, A. Gorel, G. Schiro, C. Bacellar, C. Cirelli, J.-P. Colletier, L. Foucar, M. L. Gruenbein, E. Hartmann, M. Hilpert, P. Johnson, M. Kloos, G. Knopp, B. Marekha, , I. Schlichting

This study shows that varying pump laser fluence in TR-SFX experiments affects structural dynamics and coherent oscillations in myoglobin, highlighting the need for linear photoexcitation in ultrafast studies.

bioRxiv · Nov 22, 2022 · PreprintBiophysics

Rational control of structural off-state heterogeneity in a photoswitchable fluorescent protein provides switching contrast enhancement

V. Adam, K. Hadjidemetriou, N. Jensen, R. L. Shoeman, J. Woodhouse, A. Aquila, A.-S. Banneville, T. R. M. Barends, V. Bezchastnov, S. Boutet, M. Byrdin, M. Cammarata, S. Carbajo, N.-E. Christou, N. Coquelle, , Za

This paper enhances switching contrast in photoswitchable fluorescent proteins by modifying the V151 side chain, improving performance in RESOLFT nanoscopy.

ChemPhysChem · Aug 12, 2022Peer-reviewedBiophysics

Structure of the Lysinibacillus sphaericus Tpp49Aa1 pesticidal protein elucidated from natural crystals using MHz-SFX

L. J. Williamson, M. Galchenkova, H. L. Best, R. J. Bean, A. Munke, S. Awel, G. Pena, J. Knoska, R. Schubert, K. Doerner, H.-W. Park, D. K. Bideshi, A. Henkel, V. Kremling, B. Klopprogge, , D. Oberthur

This paper determines the structure of Tpp49Aa1 using MHz-SFX and investigates its interaction with Cry48Aa1, expanding its known target range to include additional mosquito species.

bioRxiv · Jan 14, 2022 · PreprintBiochemistry

Direct Observation of the Mechanism of Antibiotic Resistance by Mix-and-Inject at the European XFEL

S. Pandey, G. Calvey, A. M. Katz, T. N. Malla, F. Koua, J. Martin-Garcia, I. Poudyal, J.-H. Yang, M. Vakili, O. Yefanov, K. A. Zielinski, S. Bajt, S. Awel, K. Doerner, M. Frank, , M. Schmidt

The paper directly observes fast ligand binding in a biomedically relevant enzyme using MHz X-ray pulses at the European XFEL.

bioRxiv · Nov 24, 2020 · PreprintBiophysics