Author

M. Kortylewski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:imaging· 2 Approach:microscopy & imaging analysis· 2

Frequent Co-Authors

J. Brooks· 2 shared P. Swiderski· 2 shared S. Forman· 2 shared S. K. Hui· 2 shared S. S. Madabushi· 2 shared B. Armstrong· 1 shared B. Kumar· 1 shared B. T. Chen· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

J. Brooks

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Local CpG-Stat3 siRNA treatment improves antitumor effects of checkpoint inhibitors

H. Yu, C. Zhang, R. Huang, L. Ren, J. Zhang, M. Kortylewski, P. Swiderski, S. Forman

This study shows that local CpG-Stat3 siRNA treatment enhances checkpoint inhibitor efficacy in mouse tumor models by improving T-cell responses.

bioRxiv · Aug 17, 2023 · PreprintImmunology

Oligo-PROTAC strategy for cell-selective and targeted degradation of activated STAT3

J. Hall, Z. Zhang, D. Wang, S. Bhattacharya, M. Alcantara, Y. Liang, P. Swiderski, S. Forman, L. Kwak, N. Vaidehi, M. Kortylewski

This paper develops a PROTAC-based strategy to selectively degrade activated STAT3 in specific cell types, showing efficacy in reducing STAT3 levels and tumor growth in lymphoma models.

bioRxiv · Aug 1, 2023Cancer Biology

Longitudinal preclinical imaging characterization of drug delivery potential after radiotherapy in the healthy and leukemic bone marrow vascular microenvironment

J. Brooks, D. Zuro, J. Y. Song, S. S. Madabushi, J. F. Sanchez, M. Kortylewski, B. T. Chen, K. Gupta, G. Storme, J. Froelich, S. K. Hui

This study uses longitudinal multiphoton imaging to assess how radiotherapy affects drug delivery in the bone marrow vasculature of healthy and leukemic mice.

bioRxiv · Feb 23, 2021 · PreprintCancer Biology

Development of Kinetic Modeling to Assess Multi-functional Vascular Response to Low Dose Radiation in Leukemia

J. Brooks, B. Kumar, D. M. Zuro, J. D. Raybuck, S. S. Madabushi, P. Vishwasrao, L. E. Parra, M. Kortylewski, B. Armstrong, S. K. Hui

The paper uses intravital multiphoton microscopy to assess vascular parameters in a leukemia mouse model and shows radiation therapy improves drug uptake.

bioRxiv · May 9, 2019 · PreprintCancer Biology