L. Ren

SMYD5 is a ribosomal methyltransferase that catalyzes RPL40 lysine methylation to enhance translation output and promote hepatocellular carcinoma

This study identifies SMYD5 as a methyltransferase that modifies RPL40 K22me3, enhancing translation and promoting hepatocellular carcinoma.

Microbial community assembly during aging of food waste-derived hydrochar: key bacterial guilds mediate nutrient dynamics

This study investigates how adding straw and microbes accelerates hydrochar aging by identifying key bacterial guilds involved in nutrient cycling.

Rbpj deletion in hepatic progenitor cells attenuates endothelial responses and fibrosis in DDC-fed mice

This study shows that deleting Rbpj in hepatic progenitor cells reduces fibrosis and endothelial responses in DDC-fed mice by downregulating VCAM1 expression.

Inhibition of mammalian mtDNA transcription paradoxically activates liver fatty acid oxidation to reverse diet-induced hepatosteatosis and obesity

The paper shows that inhibiting mitochondrial DNA transcription in mice increases fatty acid oxidation, reducing obesity and liver fat while decreasing oxidative phosphorylation capacity.

Local CpG-Stat3 siRNA treatment improves antitumor effects of checkpoint inhibitors

This study shows that local CpG-Stat3 siRNA treatment enhances checkpoint inhibitor efficacy in mouse tumor models by improving T-cell responses.

Characterization of Pik1 function in fission yeast reveals its conserved role in lipid synthesis and not cytokinesis

This study shows Pik1 in fission yeast localizes to the trans-Golgi and contributes to PI4P synthesis but not cytokinesis.

Fission yeast CK1 promotes DNA double-strand break repair through both homologous recombination and non-homologous end joining

This study shows that fission yeast CK1 orthologues Hhp1 and Hhp2 promote DNA double-strand break repair through both homologous recombination and non-homologous end joining by phosphorylating substrates like Arp8.

Membrane binding of endocytic myosin-1s is inhibited by a class of ankyrin repeat proteins

This study identifies Ank1 as a binding partner of Myo1 in fission yeast, showing it inhibits Myo1 membrane binding through interactions with the lever arm and TH1 domain, and suggests Ank1 orthologs regulate myosin-1 in endocytosis.

Target Identification and Mechanistic Characterization of Indole Terpenoid Mimics: Proper Spindle Microtubule Assembly Is Essential for Cdh1-Mediated Proteolysis of CENP-A

The paper identifies microtubule-targeting agents that induce CENP-A accumulation by destabilizing Cdh1, linking microtubule dynamics to CENP-A proteolysis.

Mimicking seasonal changes in light-dark cycle and ambient temperature modulates gut microbiome in mice under the same dietary regimen

This study shows that altering light-dark cycles and temperature in mice changes their gut microbiome composition, mimicking seasonal effects without changing diet.

Proteomics Characteristics Reveal the Risk of T1 Colorectal Cancer Metastasis to Lymph Nodes

The paper develops a proteomics-based classifier to predict lymph node metastasis in T1 colorectal cancer using protein expression patterns and machine learning.

Mechanistic basis for targeting homologous recombination defective liver cancer via synthetic lethality

This study identifies a novel subtype of HRD in HBVHCC caused by CDW19S perturbation and shows it can be targeted therapeutically.

Fatty acid binding protein 1 and fatty acid synthetase overexpression have differential effects on collagen III and cross-linking in Zongdihua pig tissues

This study investigates the effects of FABP1 and FAS overexpression on collagen III and cross-linking in Zongdihua pig tissues, identifying their roles in fat deposition.

An oligosaccharide analog exhibited antifungal activity by misleading cell wall organization via targeting PHR transglucosidases

This paper shows that a chitosan oligosaccharide analog disrupts fungal cell wall organization by targeting PHR transglucosidases, leading to antifungal activity and synergy with existing fungicides.

The infiltration pattern of microenvironmental cells and different immune escape mechanisms in colorectal cancer

The paper identifies three TME cell subtypes in colorectal cancer and their associated immune escape mechanisms using transcriptomic data from public datasets.

Natural killer-like B cells promote Th17 cell differentiation and exacerbate rheumatoid arthritis

This study identifies natural killer-like B cells as pathogenic in rheumatoid arthritis by promoting Th17 differentiation and disease severity.

Trans-epithelial migration is essential for neutrophil activation during RSV infection

This study shows that trans-epithelial migration is necessary for neutrophil activation during RSV infection, with three phases of neutrophil behavior identified.

Analysis of viral RNA-host protein interactomes enables rapid antiviral drug discovery

The paper identifies antiviral drugs by analyzing RNA-host protein interactomes of SARS-CoV-2, EBOV, and ZIKV.

Comparison of three TaqMan Real-Time Reverse Transcription-PCR assays in detecting SARS-CoV-2

This study compares three qRT-PCR assays for SARS-CoV-2 detection, finding that CCDC and IPBCAMS N gene assays outperformed WHO assays, while IPBCAMS ORF 1b assay had higher detection rates than others.

Multiple Mechanisms of HIV-1 resistance to PGT135 in Chinese Subtype B' Slow Progressor

This study identifies multiple HIV-1 escape mechanisms from PGT135 in a slow progressor, highlighting the role of glycan sites and V1/V4/C2 region changes in antibody resistance.

Rectal bacteria produce sex pheromones in the male oriental fruit fly

This study shows that bacteria in the rectum of male oriental fruit flies produce sex pheromones, specifically TMP and TTMP, which attract females.

Identification of potent and safe antiviral therapeutic candidates against SARS-CoV-2

This study identifies 24 FDA-approved compounds that inhibit SARS-CoV-2 replication, with five showing high safety indices and blocking S protein-mediated cell fusion.

Single-cell transcriptional atlas of the Chinese horseshoe bat (Rhinolophus sinicus) provides insight into the cellular mechanisms which enable bats to be viral reservoirs

This paper creates a single-cell transcriptomic atlas of the Chinese horseshoe bat to study its role as a viral reservoir, identifying cell types and receptor expression patterns related to viral entry.

Egg-surface bacteria deter oviposition by the oriental fruit fly Bactrocera dorsalis

The paper shows that egg-surface bacteria in Bactrocera dorsalis increase β-caryophyllene in fruits, deterring oviposition by conspecific flies.

Cross-reactive neutralization of SARS-CoV-2 by serum antibodies from recovered SARS patients and immunized animals

This study shows that antibodies from SARS-CoV survivors and immunized animals neutralize SARS-CoV-2, suggesting potential for broad-spectrum vaccines against emerging coronaviruses.

Humanized Single Domain Antibodies Neutralize SARS-CoV-2 by Targeting Spike Receptor Binding Domain

This study identifies humanized single domain antibodies that neutralize SARS-CoV-2 by targeting the spike receptor binding domain, showing improved activity when fused with the Fc region.

The Pathogenicity of SARS-CoV-2 in hACE2 Transgenic Mice

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

Neutrophil: Airway Epithelial Interactions Result in Increased Epithelial Damage and Viral Clearance during RSV Infection

This study shows that neutrophils enhance RSV clearance but increase airway epithelial damage through mechanisms involving activation, degranulation, and apoptosis.

Respiratory syncytial virus activates Rab5a to suppress IRF1-dependent IFN-{lambda} production, subverting the antiviral defense of airway epithelial cells

This paper identifies Rab5a as a host factor that RSV activates to suppress IRF1-dependent IFN-λ production, thereby reducing antiviral immunity in airway epithelial cells.

Vitamin A supplement after neonatal Streptococcus pneumoniae pneumonia alters CD4+T cell subset and inhibits allergic asthma in mice model

This study shows that vitamin A supplementation after neonatal Streptococcus pneumoniae pneumonia reduces allergic asthma in mice by altering CD4+ T cell subsets.