M. Kronenberg

immgenT: A Comprehensive Reference of Convergent T-cell States in the Mouse

immgenT creates a comprehensive T-cell molecular atlas across mouse organs and disease states, identifying 8 lineages and 107 clusters using deep generative models and integrating external datasets.

Genomic Specificity of Anti-TCR mAbs determined by single-cell RNAseq

The paper identifies TCR-V gene usage patterns in T cells sorted by anti-TCR mAbs using single-cell RNAseq and finds enriched ERV1-family LTR expression in specific TRBV regions.

Internal regulation between constitutively expressed T cell coinhibitory receptors BTLA and CD5 and tolerance in recent thymic emigrants

This study identifies a regulatory pathway between BTLA and CD5 in T cells that calibrates their expression to establish self-tolerance in recent thymic emigrants.

Transcriptomes and metabolism define mouse and human MAIT cell heterogeneity

This study identifies MAIT cell heterogeneity in mice and humans through single-cell RNA sequencing and metabolic analysis, revealing distinct transcriptomes and metabolic states in different tissues and species.

Specialized subsets of innate-like T cells and dendritic cells protect from lethal pneumococcal infection in the lung

The paper identifies specialized innate-like T cells and dendritic cells that contribute to protection against pneumococcal lung infection through specific cytokine production and cellular interactions.

HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160

The paper determines HVEM structures and generates mutants to reveal distinct functions of binding to LIGHT and BTLA/CD160 in immune responses.

Transcriptome and Chromatin Landscape of iNKT cells are Shaped by Subset Differentiation and Antigen Exposure

This study examines how iNKT cell subsets change in gene programs and chromatin structure across tissues and after antigen exposure, revealing long-term adaptability.

Epithelial HVEM promotes basement membrane synthesis and intraepithelial T cell survival and migration

This study shows that epithelial HVEM supports basement membrane synthesis and IET survival and migration in the intestine.