J. Burton

Discovery of active mouse, plant and fungal cytochrome P450s in endogenous proteomes and upon expression in planta.

The paper identifies active cytochrome P450s in mouse, plant, and fungal systems using chemical probes and mass spectrometry, showing their subcellular localization and activity-based labeling.

Using CombiCells, a platform enabling titration and combinatorial display of cell surface ligands, to study T cell antigen sensitivity by TCRs, CARs, and BiTEs

The paper uses CombiCells to compare T cell antigen sensitivity mediated by TCRs, CARs, and BiTEs and assess the impact of co-stimulation and co-inhibition receptors.

Glutathione transferase photoaffinity labeling demonstrates GST activation by safeners and NPR1-independent activation by BTH

The paper introduces a photoaffinity labeling assay to study GST activation in plants, showing safener-induced activation in wheat and BTH-induced activation in Arabidopsis independent of NPR1.

Inefficient exploitation of accessory receptors reduces the sensitivity of chimeric antigen receptors.

This study shows that CARs have lower antigen sensitivity than TCRs due to inefficient use of accessory receptors, and demonstrates ways to improve this sensitivity.

Cast away on Mindoro island: lack of space limits population growth of the endangered tamaraw (Bubalus mindorensis)

The study analyzes the population dynamics of tamaraws in a protected area, finding density-dependent feedbacks and range contraction despite overall population growth.

Microscopy quantification of microbial birth and death dynamics

This study uses time-lapse microscopy to quantify birth and death rates of yeast mutants in different metabolite concentrations, revealing non-intuitive dynamics better modeled by the Moser model.

Synchronous diversification of Sulawesi’s iconic artiodactyls driven by recent geological events

The paper tests the hypothesis that recent geological events on Sulawesi drove the synchronous diversification of its endemic artiodactyls, finding that species expanded from a central area that emerged above sea level ~1-2 Myr ago.