Author

D. Klein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cell Biology· 1 Immunology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:clustering· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

L. Peng· 2 shared P. Clark· 2 shared P. Ren· 2 shared S. Chen· 2 shared T. Li· 2 shared Z. Fang· 2 shared B. Behr· 1 shared B. Nelson· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersBioengineering

L. Peng

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

An integrated transcriptomic cell atlas of human endoderm-derived organoids

Q. Xu, L. Halle, S. Hediyeh-zadeh, M. Kuijs, U. Kilik, Q. Yu, T. Frum, L. Adam, S. Parikh, M. Gander, R. Kfuri-Rubens, D. Klein, Z. He, J. S. Fleck, K. Oost, , J. G. Camp

This paper creates a human endoderm organoid cell atlas by integrating single-cell transcriptomes from multiple organoid types to compare cell states with primary tissues and disease models.

bioRxiv · Nov 20, 2023Cell Biology

Desynapsis in potato is caused by StMSH4 mutant alleles and leads to either highly uniform unreduced pollen or sterility

C. R. Clot, D. Klein, J. Koopman, C. Schuit, C. J. M. Engelen, R. B. C. Hutten, M. Brouwer, R. G. F. Visser, M. Jurani?, H. J. V. Eck

This paper identifies StMSH4 mutations as the cause of desynapsis in potato, leading to either sterility or uniform unreduced pollen, and shows these alleles are common in cultivars.

bioRxiv · Feb 23, 2023 · PreprintPlant Biology

Potent and specific human monoclonal antibodies against SARS-CoV-2 Omicron variant by rapid mRNA immunization of humanized mice

P. Ren, L. Peng, Z. Fang, K. Suzuki, P. A. Renauer, Q. Lin, M. Bai, L. Yang, T. Li, P. Clark, D. Klein, S. Chen

This study develops RAMIHM, a method to generate potent human monoclonal antibodies against SARS-CoV-2 Omicron using mRNA immunization of humanized mice, identifying three highly effective antibodies.

bioRxiv · Mar 17, 2022 · PreprintBioengineering

Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617

L. Peng, Y. Hu, M. Mankowski, P. Ren, R. Chen, J. Wei, M. Zhao, T. Li, T. Tripler, L. Ye, R. Chow, Z. Fang, C. Wu, M. Dong, M. Cook, , S. Chen

The paper develops and characterizes monospecific and bispecific monoclonal antibodies that neutralize SARS-CoV-2 and its variants, including B.1.617.2 Delta.

bioRxiv · Dec 21, 2021Immunology

Genome-wide Disease Screening in Early Human Embryos with Primary Template-Directed Amplification

Y. Xia, V. Gonzales-Pena, D. Klein, J. Luquette, L. Puzon, N. Siddiqui, V. Reddy, P. Park, B. Behr, C. Gawad

This paper introduces a method to screen early human embryos for genetic variants using primary template-directed amplification, identifying aneuploidy, mitochondrial variants, and disease-causing mutations, and computing polygenic risk scores.

bioRxiv · Jul 6, 2021 · PreprintBioengineering