J. Pu

An emerging PB2-627 polymorphism increases the pandemic potential of avian influenza virus by breaking through ANP32 host restriction in mammalian and avian hosts

This paper identifies a PB2-627V mutation in avian influenza viruses that enhances pandemic potential by overcoming host restriction through ANP32A proteins in both avian and mammalian hosts.

A mechanism that transduces lysosomal damage signals to stress granule formation for cell survival

The paper identifies a calcium-dependent pathway involving ALIX that links lysosomal damage to stress granule formation, promoting cell survival in response to various stressors.

Tropism of AAV.CPP.16 in the respiratory tract and its application for a CRISPR-based gene therapy against SARS-CoV-2

This study evaluates AAV.CPP.16 as a gene delivery vector for respiratory diseases and demonstrates its use in a CRISPR-based therapy targeting SARS-CoV-2.

Quantitative Learning of Cellular Features From Single-cell Transcriptomics Data Facilitates Effective Drug Repurposing

This study introduces SuperFeat, a framework that uses single-cell transcriptomics data to identify drug targets by modeling adverse cellular states, validated in vitro and in vivo.

Evolution of a fatty acyl-CoA elongase underlies desert adaptation in Drosophila

This study identifies a fatty acyl-CoA elongase gene, mElo, as crucial for desiccation resistance in Drosophila mojavensis through evolutionary changes enabling the synthesis of long-chain methylbranched cuticular hydrocarbons.

Increased public health threat of avian-origin H3N2 influenza virus during evolution in dogs

This study identifies how avian-origin H3N2 influenza viruses adapt to dogs, acquiring traits that increase their potential to infect humans.

Integrated single-cell sequencing analysis reveals peripheral immune landscape across the human lifespan

This study uses single-cell sequencing to analyze immune cell dynamics across human lifespan, identifying age-related changes in T cell function, cell interactions, and B cell subsets.

Desiccation resistance differences in Drosophila species can be largely explained by variations in cuticular hydrocarbons

This study shows that variations in cuticular hydrocarbons, particularly methyl-branched CHCs, largely explain desiccation resistance differences among Drosophila species.

Repression precedes the stepwise evolution of a highly specific gene expression pattern

The paper traces the evolutionary origin of an enhancer that drives specific gene expression in Drosophila, showing that repressor sequences evolved before activator regions.

Contingency and chance erase necessity in the experimental evolution of ancestral proteins

This study shows that contingency and chance dominate over necessity in shaping protein sequence variation over long evolutionary timescales.

A valid protective immune response elicited in rhesus macaques by an inactivated vaccine is capable of defending against SARS-CoV-2 infection

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

Inhibition of ITK differentiates GVT and GVHD in allo-HSCT

This paper shows that inhibiting ITK in donor T cells reduces GVHD while preserving GVT effects in allo-HSCT using murine models and a novel peptide inhibitor.

Birth-and-death evolution of the fatty acyl-CoA reductase (FAR) gene family and diversification of cuticular hydrocarbon synthesis in Drosophila

The paper investigates the evolutionary dynamics of the FAR gene family in Drosophila, finding that genes involved in cuticular hydrocarbon synthesis show higher instability compared to those in essential fatty acid pathways.

Beyond a ribosomal RNA methyltransferase, the wider role of MraW in DNA methylation, motility and colonization in Escherichia coli O157:H7

This paper identifies MraW as a DNA methylase in E. coli O157:H7, showing its role in motility, colonization, and virulence through genome-wide methylation and regulation of flagellar genes.