R. Yan

The Class III peroxidase OsPrx20 is a key regulator of stress response and growth in rice

This study identifies OsPrx20 as a key regulator of stress response and growth in rice, showing its dual role in osmotic stress tolerance and blast resistance.

Architecture and flexibility of native kinetochores revealed by structural studies utilizing a thermophilic yeast

This study reveals the architecture and flexibility of native kinetochores using structural analyses of purified kinetochores from thermophilic yeast.

Molecular basis of inhibition of the amino acid transporter B0AT1 (SLC6A19)

This paper identifies high-affinity inhibitors of B0AT1 and elucidates their mechanism of action through cryo-EM structures.

Bio-inspired mineralization collagen induce fibrocartilage regeneration after tendon-bone injury by activating Gli1+Dkk3+ progenitor cells

This study develops a bio-inspired hydrogel that promotes tendon-bone interface regeneration by activating Gli1+Dkk3+ progenitor cells, achieving 68% mechanical recovery.

Epidemiological evaluation and identification of the insect vector of soybean stay-green associated virus

This study identifies SoSGV as the causative agent of soybean stay-green syndrome and confirms the common brown leafhopper as its vector, revealing its epidemiology and geographical spread.

Single-molecule displacement mapping unveils sign-asymmetric protein charge effects on intraorganellar diffusion

The paper uses single-molecule displacement mapping to show that positive charges impede protein diffusion in organelles, while negative charges do not, with an exception in the ER protein PPIB.

Assembly of gut-derived bacterial communities follows "early-bird" resource utilization dynamics

This study shows that gut microbiota assembly follows 'early-bird' dynamics where fast-growing species dominate nutrient sources, and develops a predictive model for community composition based on nutrient inputs.

Structural basis for the assembly of the DNA polymerase holoenzyme from a monkeypox virus variant

This study determines the cryo-EM structure of the MPXV DNA polymerase holoenzyme F8/A22/E4, revealing its dimeric assembly and auto-inhibition state, with implications for antiviral drug design.

The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins

This paper shows SARS-CoV-2 Orf3a is not an ion channel but interacts with trafficking proteins, while SARS-CoV-1 Orf3a does not.

Structural basis for the enhanced infectivity and immune evasion of Omicron subvariants

This study reports cryo-EM structures of Omicron subvariant S proteins, revealing conformational differences linked to transmissibility and immune evasion.

Conditional forest models built using metagenomic data could accurately predict Salmonella contamination in Northeastern streams

This paper uses metagenomic data from Northeastern streams to predict Salmonella contamination using conditional forest models, finding Aeromonas and Tabrizicola as key indicators.

Ticagrelor combined with aspirin displays the signature of regulating the gut microbiome in consistence with improving the immuno-inflammatory response in atherosclerosis

The paper was withdrawn due to insufficient cell culture data to clarify the mechanism of ticagrelor and aspirin's effect on the gut microbiome and immuno-inflammatory response in atherosclerosis.

In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes

This study uses cryo-electron tomography to reveal the asymmetric protein complexes in mammalian sperm axonemes, explaining their unique flagellar beating pattern.

T cell-mediated development of stromal fibroblasts with an immune-enhancing chemokine profile

The paper shows that stromal fibroblasts can switch from an immune-suppressive to an immune-activating chemokine profile in response to T cell-derived cytokines.

An intergeneric recombinant geminivirus causes soybean stay-green disease

This paper identifies a novel intergeneric recombinant geminivirus as the cause of soybean stay-green disease, showing it induces symptoms and can be detected in seed coats but not seeds.

The bladder microbiome, metabolome, cytokines, and phenotypes in patients with systemic lupus erythematosus

This study examines the bladder microbiome, metabolome, and cytokines in SLE patients, finding associations between microbial composition and disease-related metabolites and cytokines.

The endoplasmic reticulum adopts two distinct tubule forms

The paper identifies two distinct ER tubule forms, R1 and R2, regulated by Rtn4 and Climp63, with functional implications for ER structure and dynamics.

CryoEM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition

This study reveals how EBV's BORF2 protein inhibits APOBEC3B by blocking its access to DNA, providing insights for drug development.

Displacement statistics of unhindered single molecules show no enhanced diffusion in enzymatic reactions

The paper measures diffusion coefficients of four enzymes under catalytic conditions and finds no enhanced diffusion.

Structural basis for sterol sensing by Scap and Insig

This study determines the structure of the Scap/Insig-2 complex in the absence of 25HC, revealing structural insights into cholesterol sensing and regulatory mechanisms.

A new type of ERGIC-ERES membrane contact mediated by TMED9 and SEC12 is required for autophagosome biogenesis

The paper identifies a new ERGIC-ERES membrane contact mediated by TMED9 and SEC12 that is essential for autophagosome biogenesis under stress.

Excitation spectral microscopy for highly multiplexed fluorescence imaging and quantitative biosensing

This paper introduces excitation spectral microscopy to enable high multiplexing of fluorescent targets in live cells with low crosstalk and high temporal resolution.

Tubular ERGIC (t-ERGIC): a SURF4-mediated expressway for ER-to-Golgi transport

This study identifies a tubular ERGIC (t-ERGIC) formed by SURF4 that enhances ER-to-Golgi transport of specific cargoes through unique structural and functional properties.

ACE2-Targeting Monoclonal Antibody as Potent and Broad-Spectrum Coronavirus Blocker

This paper reports a monoclonal antibody, 3E8, that blocks multiple coronaviruses by targeting ACE2, showing broad-spectrum activity against SARS-CoV-2 variants and other coronaviruses.

Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies

This study reports cryo-EM structures of potent SARS-CoV-2 neutralizing antibodies, revealing bivalent binding mechanisms and their correlation with enhanced neutralization and S1 subunit shedding.

SingleChannelNet: A Model for Automatic Sleep Stage Classification with Raw Single-Channel EEG

SingleChannelNet is a deep learning model that automatically classifies sleep stages from raw single-channel EEG data, achieving high accuracy without hand-crafted features or multi-modality data.

Pancreatic cancer cells assemble a CXCL12-keratin 19 coating to resist immunotherapy

The paper shows pancreatic cancer cells use transglutaminase-2 to create CXCL12-keratin 19 coatings that block T cells and resist immunotherapy.

Engineered Trimeric ACE2 Binds and Locks "Three-up" Spike Protein to Potently Inhibit SARS-CoVs and Mutants

This study engineers a trimeric ACE2 protein that binds the spike protein with high affinity, inhibiting SARS-CoVs and mutants by locking the spike in a 'three-up' conformation.

Probing nanoscale diffusional heterogeneities in cellular membranes through multidimensional single-molecule and super-resolution microscopy

The paper uses single-molecule and super-resolution microscopy to map nanoscale diffusional heterogeneities in live mammalian cell membranes, revealing differences in diffusivity across membrane regions and identifying protein crowding as a potential cause.

A potent neutralizing human antibody reveals the N-terminal domain of the Spike protein of SARS-CoV-2 as a site of vulnerability

This paper identifies a potent neutralizing antibody targeting the N-terminal domain of SARS-CoV-2 Spike protein, revealing it as a new therapeutic target.