S. Broer

Molecular basis of inhibition of the amino acid transporter B0AT1 (SLC6A19)

This paper identifies high-affinity inhibitors of B0AT1 and elucidates their mechanism of action through cryo-EM structures.

Cell-specialized chloroplast signaling orchestrates photosynthetic and extracellular reactive oxygen species for stress responses

This study identifies how chloroplast retrograde signals like PAP coordinate ROS production in guard cells to regulate stomatal closure during stress.

Coordinated Action of Multiple Transporters in the Acquisition of Essential Cationic Amino Acids by the Intracellular Parasite Toxoplasma gondii

This study identifies TgApiAT6-1 as a second arginine transporter in Toxoplasma gondii, showing it mediates both lysine and arginine uptake and is essential for parasite proliferation.

Restriction of essential amino acids dictates the systemic response to dietary protein dilution

This study shows that restricting essential amino acids, not non-essential ones, drives systemic metabolic responses to dietary protein dilution and genetic amino acid transport loss.

Characterization of the apicomplexan amino acid transporter (ApiAT) family in Toxoplasma gondii

The paper identifies and characterizes the ApiAT family of amino acid transporters in Toxoplasma gondii, showing their role in amino acid scavenging and parasite virulence.