M. Kinoshita

This study develops an mRNA vaccine targeting Pseudomonas aeruginosa's type III secretion system, showing improved mouse survival and reduced lung bacterial load after challenge.

The paper identifies 12 transcriptional gene programs in CD4+ T cells from autoimmune diseases and shows their utility in disease characterization and prediction.

This study identifies the conserved GYXLI motif in FlhA as critical for dynamic domain motions in FlhAC, enabling efficient flagellar protein export via the fT3SS.

This study shows that overexpressing adenylate kinase 1 in medaka fish increases locomotor activity, which is temperature-dependent.

This study identifies neuromuscular gene expression in thymoma-associated myasthenia gravis by analyzing bulk and single-cell RNA-seq data, linking it to specific thymic epithelial cell subpopulations.

This study identifies a unique adhesive motif in P5 that enables dimerization, which is essential for its structural stability and functional roles in ER quality control.

The paper determines the native structure of the bacterial flagellar MS ring, revealing it is 34-fold symmetric with 23-fold and 11-fold subsymmetries in its inner and middle regions.

The paper identifies FlhA's linker as a switch that regulates flagellar protein export specificity during assembly by interacting with FlhAC to control chaperone binding.

The paper investigates how membrane voltage influences flagellar protein export by showing that a voltage increase recovers export in the absence of ion gradients.

The paper identifies FlgN as a chaperone that activates the Na+-driven export mechanism in the absence of the ATPase complex in bacterial flagellar protein export.

This study examines the expression of Ace2, Tmprss2, and Furin in mouse ear tissues, finding co-expression in the middle ear that suggests susceptibility to SARS-CoV-2.

This study shows that LPS preconditioning enhances phagocytic clearance of malaria parasites by liver macrophages, improving survival in mice infected with Plasmodium yoelii.

This study generates a TBT-bp2 knockout medaka strain to investigate the function and detoxification mechanisms of tributyltin-binding proteins.

The paper measures serum titers against five Gram-negative bacterial V-antigens in adults and finds high cross-correlation between some antigens, suggesting potential for epidemiological studies.

This study shows that zinc enhances EGCG's ability to inhibit hIAPP amyloid aggregation both in solution and in the presence of lipid membranes.

The paper identifies a lncRNA/miRNA/DNA methylation axis that regulates the timing of stem cell state transition from naive pluripotency.