M. P. Zafra

This study develops a murine system for temporal and regulatable in vivo cytosine base editing to rapidly generate preclinical cancer models with specific SNVs.

The paper creates KRAS mutant mouse models to study how different oncogenic variants affect tumor development and therapy response in vivo.

This study identifies lineage reversion as a mechanism enabling WNT-independent growth in intestinal cancer by integrating genetic alterations and extracellular signals.

The paper introduces a functional reporter system called GO to identify and enrich base editing activity in cells with high sensitivity and specificity.