R. A. Melnyk

The paper identifies commensal Pseudomonas strains that protect Arabidopsis from pathogens through colonization-dependent mechanisms, revealing a response regulator involved in competitive exclusion.

The paper determines high-resolution structures of DT homologs to investigate their host adaptation and toxicity mechanisms.

This paper introduces bioPROTACs as intracellular biologics for targeted protein degradation, demonstrating their effectiveness against PCNA with rapid degradation and functional effects.

This study creates a chimera of diphtheria toxin and TPP1 to enhance lysosomal enzyme delivery, showing improved uptake and efficacy in a mouse model.

This paper develops a chimeric toxin that cleaves both mutant and wild-type RAS, reducing tumor burden in mouse models.

The paper identifies genomic islands linked to pathogenic and commensal lifestyles in Pseudomonas fluorescens using computational analysis of Arabidopsis-associated strains.

This paper identifies bacterial genes in Pseudomonas sp. WCS365 that enhance rhizosphere fitness and evade Arabidopsis plant defenses through biofilm formation and immune response modulation.

The paper identifies novel enzymes filling amino acid biosynthesis gaps in bacteria using genome-wide mutant fitness data, revealing previously unknown pathways for methionine, threonine, serine, and histidine synthesis.