Didemnin B and ternatin-4 inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes
M. F. Juette, J. D. Carelli, E. J. Rundlet…·S. C. Blanchard
This study shows how didemnin B and ternatin-4 inhibit translation by trapping eEF1A in a GTPase-activated conformation using single-molecule imaging and cryo-EM.