Tumour-derived extracellular vesicles within the therapy-induced senescent secretome distinctly suppress breast cancer via DKK1-mediated inflammatory response.
M. Robert, R. Jakhar, B. V. Au, G. W. L. Eng, M. Wei, A. K. Gao, Y. H. Chuah, K. Sachaphibulkij, I. Bonne, K. J. Lim, I. Sinha, D. B. L. Teh, L. H. K. Lim, P. Kumar, N. K. Verma, , K. C. Crasta
This study identifies that TIS-derived extracellular vesicles suppress breast cancer through DKK1-mediated inflammation, contrasting with the pro-tumorigenic effects of the senescence-associated secretome.
bioRxiv · Mar 29, 2024 · PreprintCancer Biology