Metabolic control of adaptive β-cell proliferation by the protein deacetylase SIRT2
M. Wortham, B. Ramms, C. Zeng, J. R. Benthuysen, S. Sai, D. P. Pollow, F. Liu, M. Schlichting, A. R. Harrington, B. Liu, T. P. Prakash, E. C. Pirie, H. Zhu, S. Baghdasarian, J. Auwerx, , M. Sander
This study identifies SIRT2 as a regulator of β-cell proliferation, showing its role in controlling β-cell expansion during hyperglycemia while preserving feedback mechanisms.
bioRxiv · Feb 24, 2024 · PreprintPhysiology