M. Sharon

The C-terminal tail of CSNAP attenuates the CSN complex

The paper shows that a C-terminal peptide from CSNAP can displace CSNAP from the CSN complex, reducing CSN activity and CRL function, suggesting a new therapeutic approach.

A counter-enzyme complex regulates glutamate metabolism in Bacillus subtilis

The paper identifies a counter-enzyme complex in Bacillus subtilis that regulates glutamate metabolism by inhibiting GudB activity, essential for growth under varying glutamate conditions.

Insight into the autosomal-dominant inheritance pattern of SOD1-associated ALS from native mass spectrometry

The paper uses native mass spectrometry to analyze SOD1 subunit association in ALS, finding a correlation between coupling constants and disease duration.

The inter-dimeric interface controls function and stability of Ureaplasma urealiticum methionine S-adenosyltransferase

This study shows that the inter-dimeric interface of U. urealiticum MAT regulates catalytic activity and structural stability through conformational changes induced by product binding.

Regulation of the 20S proteasome by a novel family of inhibitory proteins

The paper identifies a family of 20S proteasome regulators, CCRs, that modulate proteasome activity through a feed-forward loop involving Nrf2 and oxidative stress response.

CSNAP, the smallest CSN subunit, modulates proteostasis through cullin-RING ubiquitin ligases

This study identifies CSNAP as a key subunit of the CSN complex that modulates CRL activity through steric inhibition, affecting cell viability and DNA damage response.

Conformational states during vinculin unlocking differentially regulate focal adhesion properties

This study investigates how vinculin's conformational changes affect focal adhesion properties by analyzing the transition from closed to open states.