Induced aneuploidy disrupts MCF10A acini formation and CCND1 expression
M. Waschow, Q. Wang, P. Saary, C. Klein, S. Aschenbrenner, K. Jechow, L. Maier, S. Tirier, B. Schoell, I. Chudoba, C. Dietz, D. Dreidax, A. Jauch, M. Sprick, C. Herrmann, , C. Conrad
This study shows that induced aneuploidy disrupts MCF10A acini formation and upregulates CCND1 expression through altered promoter-enhancer interactions.
bioRxiv · Dec 15, 2019 · PreprintCancer Biology