Vimentin Intermediate Filaments Can Enhance or Abate Active Cellular Forces in a Microenvironmental Stiffness-Dependent Manner
F. Alisafaei, K. Mandal, M. Swoger, H. Yang, M. Guo, P. Janmey, A. E. Patteson, V. Shenoy
This study shows vimentin intermediate filaments modulate cell-generated forces depending on microenvironment stiffness, increasing forces on stiff matrices and decreasing them on soft matrices.
bioRxiv · Apr 2, 2022 · PreprintBiophysics