M. Bates

Super-resolution going viral: T4 virus particles as perfect nature-designed 3D-Bio-NanoRulers

The paper introduces bacteriophage T4 as a 3D bio-ruler for super-resolution imaging, demonstrating its structure and potential as a benchmark.

Endogenous BAX and BAK form mosaic rings of variable size and composition on apoptotic mitochondria

The paper shows that BAX and BAK form mosaic rings on apoptotic mitochondria, with BAK recruiting first and both proteins forming rings independently in knockout cells.

The Drosophila MIC10 orthologue has a propensity to polymerize into cristae-shaping filaments

This study identifies DmMIC10b as the major MIC10 orthologue in Drosophila, showing it polymerizes into cristae-shaping filaments that affect mitochondrial structure and fly lifespan.

Temporal Application of Lysyl Oxidase during Hierarchical Collagen Fiber Formation Differentially Effects Mechanics in Engineered Tissues

This study evaluates the effect of LOX treatment timing on collagen fiber formation and mechanics in engineered tissues, finding that LOXL2 supplementation at 4 weeks improves crosslinking and tissue strength.

Heparins enhance C1 esterase inhibitor activity: a promising remedy for acute hereditary angioedema

This study shows low-molecular weight heparins enhance C1-INH activity in HAE patients and in vitro, suggesting they could be a cost-effective treatment for acute HAE.

Pericentriolar matrix integrity relies on cenexin and Polo-Like Kinase (PLK)1

This study identifies cenexin's role in maintaining pericentriolar matrix integrity through PLK1-dependent phosphorylation in human and zebrafish cells.

Optimal Precision and Accuracy in 4Pi-STORM using Dynamic Spline PSF Models

This paper develops a 4Pi-STORM microscope with dynamic spline PSF models to achieve high 3D resolution and accuracy in single molecule localization microscopy.

Rab11 endosomes coordinate centrosome number and movement following mitotic exit

This study shows Rab11-endosomes regulate centrosome movement and abscission by controlling pericentrin organization in human and zebrafish cells.

A remarkably specific ligand reveals ghrelin O-acyltransferase interacts with extracellular peptides and exhibits unexpected cellular localization for a secretory pathway enzyme

This study identifies a specific ligand that shows GOAT interacts with extracellular ghrelin and facilitates its internalization, revealing new insights into its catalytic mechanism and signaling role.

Vimentin intermediate filaments mediate cell shape on visco-elastic substrates

This study shows vimentin enhances cell spreading on viscoelastic substrates but not elastic ones, suggesting it modulates cell mechanosensing.

Multi-proxy evidence for the impact of the Storegga Slide Tsunami on the early Holocene landscapes of the southern North Sea

The paper identifies Storegga Slide tsunami deposits in the southern North Sea using seismic surveys, sediment cores, and dating methods, showing localized and temporary impacts.

Laboratory Analysis of an Outbreak of Candida auris in New York from 2016 to 2018-Impact and Lessons Learned

This study analyzes a C. auris outbreak in New York, identifying factors contributing to its spread and demonstrating the effectiveness of new detection methods.

Modulating cellular cytotoxicity and phototoxicity of fluorescent organic salts through counterion pairing

This paper develops a platform to independently control cytotoxicity and phototoxicity of fluorescent organic salts through counterion pairing for optoelectronic tuning.

A toolbox of anti-mouse and rabbit IgG secondary nanobodies

This paper introduces sustainable nanobodies against mouse and rabbit IgG as alternatives to traditional animal-derived secondary antibodies, demonstrating their utility in various imaging and detection applications.

Gpufit: An open-source toolkit for GPU-accelerated curve fitting

Gpufit accelerates nonlinear parameter estimation using GPU computing, achieving 42x speedup over CPU-based methods without loss of precision.