C. Ying

Elucidating the kinetic and thermodynamic insight into regulation of glycolysis by lactate dehydrogenase and its impact on tricarboxylic acid cycle and oxidative phosphorylation in cancer cells

This study investigates how lactate dehydrogenase (LDH) regulates glycolysis, TCA cycle, and oxidative phosphorylation in cancer cells through kinetic and thermodynamic mechanisms, showing that LDH inhibition disrupts metabolic pathways and induces cell death under hypoxia.

Cryo-EM led analysis of open and closed conformations of Chagas vaccine candidate TcPOP and its antibody response characterisation

This study determines the 3D structures of TcPOP in open and closed conformations using cryo-EM and evaluates its immunogenicity through antibody responses in mice.

Structural Flexibility and Disassembly Kinetics of Single Ferritins using Optical Nanotweezers

This study uses optical nanotweezers to investigate how ascorbic acid and pH affect single ferritin disassembly, identifying key fragments and cooperative behavior.

Simultaneous Determination of the Size and Shape of Single α-Synuclein Oligomers in Solution

This paper uses nanopore measurements to determine the size and shape of single α-synuclein oligomers in solution, revealing stable sub-populations with specific monomer counts.

Hsp22 is the key sensor and balancer in mitochondrial dynamic associated metabolic reprogramming

The paper shows that Hsp22 overexpression reverses metabolic reprogramming and pathogenic phenotypes in tumor and Parkinson's disease models by restoring mitochondrial homeostasis.

Identification and quantification of Lyme pathogen strains by deep sequencing of outer surface protein C (ospC) amplicons

The paper develops a deep sequencing method to identify and quantify Lyme pathogen strains by analyzing the ospC gene in ticks, revealing mixed infections and a new strain related to Borreliella bissettiae.