New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention and Cure
H. Li, S. Wang, F.-H. Lee, R. S. Roark, A. I. Murphy, J. Smith, C. Zhao, J. Rando, N. Chohan, Y. Ding, E. Kim, E. Lindemuth, K. J. Bar, I. Pandrea, C. Apetrei, , G. M. Shaw
This paper demonstrates that SHIVs with bulky aromatic amino acid substitutions at Env375 replicate efficiently in rhesus macaques and can be used for preclinical HIV vaccine testing.
bioRxiv · Jan 13, 2021Microbiology