G. M. Shaw

This study shows that germline-targeting SCIVs can activate and expand B cells expressing V2-apex bnAb-like precursors in rhesus macaques.

This study investigates how the timing of ART initiation affects viral rebound in infant SHIV-infected Rhesus macaques, finding that latent reservoir size and high-potency neutralizing antibodies influence rebound time.

This study tracks changes in the vaginal microbiome and inflammation across the reproductive cycle, finding that childbirth disrupts microbial communities and reduces Lactobacillus dominance, with limited recovery over one year.

This study identifies a new class of V2-directed cross-neutralizing antibodies targeting a cryptic epitope in occluded-open HIV and SIV Env trimers.

This paper demonstrates that SHIVs with bulky aromatic amino acid substitutions at Env375 replicate efficiently in rhesus macaques and can be used for preclinical HIV vaccine testing.

The paper identifies Fab-dimerized glycan-reactive antibodies in HIV-infected macaques and HIV-naïve humans that neutralize HIV-1 and can be elicited by vaccination.

This paper develops and validates an LC/MS/MS method to quantify ceramides and dihydroceramides in human serum, revealing unique gestational patterns during pregnancy.

This paper develops an infant rhesus macaque model of SHIV infection and analytical treatment interruption to study viral rebound and identify biomarkers for pediatric HIV functional cure strategies.

This paper evaluates three clade C SHIVs for oral transmission and infection in infant rhesus macaques, finding varied chronic viremia levels and seroconversion thresholds.

This study compares HIV-specific antibody kinetics in infant and adult rhesus macaques infected with SHIV, finding similar antibody responses despite differences in Tfh and germinal center B cell dynamics.

This study shows that high serum neutralizing antibody titers from Env protein vaccination protect rhesus macaques from Tier 2 SHIV challenge, with ~1:500 ID50 titers providing over 90% protection.

This study uses metagenomic analysis with strain-level resolution to examine the human pregnancy microbiome, revealing gestational age and health complications influence microbial community composition and function.

The paper identifies hundreds of new bacteria and viruses in the human microbiome using blood-based shotgun sequencing and validates their existence through independent experiments and PCR.