Author

G. Randall

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Microbiology· 3 Pathology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 7 Organism:human· 4 Organism:mouse· 4 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Assay:protein structure· 2

Frequent Co-Authors

V. Nicolaescu· 6 shared H. Gula· 4 shared K. Furlong· 3 shared M. Nguyen· 3 shared N. Drayman· 3 shared S. Dvorkin· 3 shared S. Tay· 3 shared A. C. Tremain· 2 shared

Activity by Year

2020-2022 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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Curved chords = mutual co-authorship

6 shared papersMicrobiology

V. Nicolaescu

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Superiority of intranasal over systemic administration of bioengineered soluble ACE2 for survival and brain protection against SARS-CoV-2 infection

L. Hassler, J. Wysocki, J. T. Ahrendsen, M. Ye, I. Gelarden, V. Nicolaescu, A. Tomatsidou, H. Gula, C. Cianfarini, N. Khurram, Y. Kanwar, B. D. Singer, G. Randall, D. M. Missiakas, J. Henkin, D. Batlle

This study compares intranasal and systemic administration of bioengineered soluble ACE2 in mice, finding intranasal delivery provides better survival and brain protection against SARS-CoV-2.

bioRxiv · Dec 5, 2022 · PreprintPathology

SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1α/XBP1 ER stress pathway in human lung-derived cells

L. C. Nguyen, D. M. Renner, D. Silva, D. Yang, N. Parenti, K. M. Medina, V. Nicolaescu, H. Gula, N. Drayman, A. Valdespino, A. Mohamed, C. Dann, K. Wannemo, L. Robinson-Mailman, A. Gonzalez, , S. R. Weiss

This study compares how SARS-CoV-2 and other betacoronaviruses activate the IRE1α/XBP1 ER stress pathway in human lung cells, finding that SARS-CoV-2 only partially activates it, potentially evading host immune detection.

bioRxiv · Dec 30, 2021 · PreprintMicrobiology

Polymersomes decorated with SARS-CoV-2 spike protein receptor binding domain elicit robust humoral and cellular immunity

L. R. Volpatti, R. P. Wallace, S. Cao, M. Raczy, R. Wang, L. T. Gray, A. T. Alpar, P. S. Briquez, N. Mitrousis, T. M. Marchell, M. S. Sasso, M. Nguyen, A. Mansurov, E. Budina, A. Solanki, , J. Hubbell

This study develops a subunit nanovaccine using polymersomes decorated with SARS-CoV-2 RBD, showing enhanced neutralizing antibody and T cell responses in mice.

ACS Central Science · Jul 21, 2021Peer-reviewedBioengineering

Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant

L. T. Gray, M. M. Raczy, P. S. Briquez, T. M. Marchell, A. T. Alpar, R. P. Wallace, L. R. Volpatti, M. S. Sasso, S. Cao, M. Nguyen, A. Mansurov, E. Budina, E. A. Watkins, A. Solanki, N. Mitrousis, , J. A. Hubbell

This paper demonstrates that conjugating the SARS-CoV-2 Spike protein to a polymeric glyco-adjuvant elicits strong cellular and humoral immune responses in mice.

bioRxiv · May 20, 2021Bioengineering

A novel soluble ACE2 protein totally protects from lethal disease caused by SARS-CoV-2 infection

L. Hassler, J. Wysocki, I. Gelarden, A. Tomatsidou, H. Gula, V. Nicoleascu, G. Randall, J. Henkin, A. Yeldandi, D. Batlle

This paper describes a soluble ACE2 protein that prevents lethal SARS-CoV-2 infection in mice by blocking viral entry and reducing viral titers.

bioRxiv · Mar 12, 2021 · PreprintPathology

Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response

L. C. Nguyen, D. Yang, V. Nicolaescu, T. Best, S. Chen, J. B. Friesen, N. Drayman, A. Mohamed, C. Dann, D. Silva, H. Gula, K. A. Jones, J. M. Millis, B. C. Dickinson, S. Tay, , M. R. Rosner

This study shows that cannabidiol inhibits SARS-CoV-2 replication and enhances the host innate immune response in lung cells and human patients.

bioRxiv · Mar 10, 2021 · PreprintMicrobiology

Nanotraps for the containment and clearance of SARS-CoV-2

M. Chen, J. Rosenberg, X. Cai, A. C. H. Lee, J. Shi, M. Nguyen, T. Wignakumar, V. Mirle, A. J. Edobor, J. Fung, J. S. Donington, K. Shanmugarajah, E. B. Chang, G. Randall, P. Penaloza-MacMaster, , J. Huang

This paper introduces Nanotraps, functionalized nanoparticles that block SARS-CoV-2 infection by inhibiting spike protein-ACE2 interaction and triggering macrophage-mediated viral clearance.

bioRxiv · Feb 1, 2021Bioengineering

Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro

N. Drayman, K. A. Jones, S.-A. Azizi, H. M. Froggatt, K. Tan, N. Ivanova Maltseva, S. Chen, V. Nicolaescu, S. Dvorkin, K. Furlong, R. S. Kathayat, M. R. Firpo, V. Mastrodomenico, E. A. Bruce, M. M. Schmidt, , S. Tay

The paper screens 1,900 drugs to find inhibitors of SARS-CoV-2 replication, identifies masitinib as a 3CLpro inhibitor effective in vitro, and shows its broad anti-viral activity.

bioRxiv · Aug 31, 2020Microbiology