Cancer BiologybioRxiv
Low-dose IFN-γ induces tumor cell stemness in tumor microenvironment of non-small cell lung cancer
Y. Zhang, M. Song, Y. Ping…·L. Wang
This study shows low-dose IFN-γ promotes tumor stemness in NSCLC via ICAM1-PI3K-Akt-Notch1 pathway, while high-dose IFN-γ induces apoptosis through JAK1-STAT1-caspase pathway.
DOI 10.1158/0008-5472.can-19-0596